Results 131 to 140 of about 1,318,427 (218)

Cell-Free DNA-Derived Immune Cell Ratios Uncover Cancer-Associated Systemic Changes. [PDF]

Cancer Res Commun
Andersen L, Lindskrog SV, Nordentoft I, Frydendahl A, Nors J, Henriksen TV, Rasmussen MH, Iversen LH, Gotschalck KA, Jensen JB, Dyrskjøt L, Andersen CL, Birkbak NJ.   +12 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

cfGWAS reveal genetic basis of cell-free DNA end motifs. [PDF]

Nat Commun
Zhu H, Zhang Y, Li L, Zeng S, Zhang X, Lin Y, Ou R, Wang L, Li X, Wang Y, Zeng J, Lin Y, Xu C, Zeng G, Li L, Zhao R, Jia Y, Luo F, Yang M, Hu Y, Xiao H, Xu X, Wang J, Zhou A, Zhang H, Jin X.   +25 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Multimodal analysis of cell-free DNA identifies epigenetic biomarkers for amyotrophic lateral sclerosis diagnosis and progression. [PDF]

J Clin Invest
Michels S, Chen C, Ruf WP, Garcia Garcia MM, Arnold FJ, Wu Z, Bennett CL, Shams D, Thompson LM, Walker AC, Dickson DW, Petrucelli L, Dorst J, Prudencio M, Li W, La Spada AR.   +15 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

TP53 mutations on circulating cell-free DNA

EBioMedicine, 2016
Klaus Pantel
doaj   +1 more source

Reduction in Donor-Derived Cell-Free DNA After Rejection Treatment is Associated With Improved Long Term Allograft Function. [PDF]

Clin Transplant
Schumacher L, Philippart O, Yau J, Shuaib F, Paluri S, Castellanos AL, Schadler A, Fattah H.   +7 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Circulating cell-free DNA in hematological malignancies

Haematologica, 2016
Lieselot Buedts, Peter Vandenberghe
doaj   +1 more source