Results 81 to 90 of about 1,661,955 (279)

Selective Targeting to Glioma with Nucleic Acid Aptamers [PDF]

, 2015
Malignant glioma is characterised by a rapid growth rate and high capacity for invasive infiltration to surrounding brain tissue; hence, diagnosis and treatment is difficult and patient survival is poor.
Alder, Jane Elizabeth, Aptekar, Shraddha Ashok, Arora, Mphit, Ashton, K, Dawson, Tim, Lawrence, Clare Louise, Lea, Robert William, Shaw, Lisa   +7 more
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell Sheet Engineering in Periodontology: A Review [PDF]

Journal of Clinical and Diagnostic Research
Cell sheet engineering has developed its own place for the regeneration of tissues. It focuses on phenomena occurring at the cellular level, whereas regenerative medicine and tissue engineering aim to create or stimulate new tissue for the treatment of ...
Ruchita Tejrao Patil, Prasad V Dhadse, Shrishti Salian   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A Revolution in Cellular Aging: A Narrative Review of the Promising Role of Nanorobots in Diagnosis, Treatment, and Regenerative Medicine [PDF]

Taṣvīr-i salāmat
Nanorobots, also known as nanobots, are promising medical structures with significant potential for revolutionizing medical treatments and preventing their onset. Nanorobotics shows promise for diagnosing, treating, and regenerating age-related diseases.
Peyman Keyhanvar, Mohammad Hossein Rezaei, Hakimeh Hazrati, Solmaz Hazratgholizad, Ahmadreza Safar Bakhshayesh   +4 more
doaj   +1 more source

Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering. [PDF]

, 2019
Prenatal stem cell-based regenerative therapies have progressed substantially and have been demonstrated as effective treatment options for fetal diseases that were previously deemed untreatable. Due to immunoregulatory properties, self-renewal capacity,
Farmer, Diana L, Guo, Fuzheng, Hao, Dake, He, Chuanchao, Lankford, Lee, Ma, Bowen, Reynaga, Lizette, Wang, Aijun   +7 more
core   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Exploring the application value of ultrasound in animal studies of stem cell therapy for intrauterine adhesions

Scientific Reports
Endometrial damage leads to intrauterine adhesions (IUA), significantly impairing endometrial receptivity and fertility. Stem cell therapies, particularly umbilical cord mesenchymal stem cell (UC-MSCs), have shown promise in regenerating damaged ...
Siqi Guo, Wencong Li, Xiaoran Chen, Meijuan Liu   +3 more
doaj   +1 more source

In Vitro and In Ovo CAM Model Evaluation of Periosteum-Derived Micrografts

Journal of Functional Biomaterials
Despite advances in periodontal regenerative therapies, consistent tissue regeneration remains challenging, with cells playing an essential role in successful repair.
Rawan Almujaydil, Conor J. McCann, Linh Nguyen, Francesco D’Aiuto   +3 more
doaj   +1 more source