Results 71 to 80 of about 1,974,930 (309)
STAR ProtocolsSummary: Secondary lymphoid organs are highly organized for the initiation of immune responses. Here, we present a protocol that enables this microanatomical structure to be preserved during short-term culture, allowing ex vivo modeling of human innate ...
Joannah R. Fergusson +3 more
doaj +1 more source
Visualizing Cellular Dynamics and Protein Localization in 3D Collagen
STAR Protocols, 2020 Summary: Immune cells migrate and communicate through cell-to-cell interactions and cytokines to coordinate the specificity and timing of the immune response.
Wan Hon Koh +3 more
doaj +1 more source
Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation [PDF]
, 2016 Background: Casitas B-lineage lymphoma (Cbl or c-Cbl) is a RING ubiquitin ligase that negatively regulates protein tyrosine kinase (PTK) signalling. Phosphorylation of a conserved residue (Tyr371) on the linker helix region (LHR) between the substrate ...
Ahmed, Syed Feroj +7 more
core +2 more sources
Emerging PCR-based techniques to study HIV-1 reservoir persistence [PDF]
, 2020 While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound.
Cole, Basiel +4 more
core +2 more sources
Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle +5 more
wiley +1 more source
Active Gel Model of Amoeboid Cell Motility
, 2013 We develop a model of amoeboid cell motility based on active gel theory. Modeling the motile apparatus of a eukaryotic cell as a confined layer of finite length of poroelastic active gel permeated by a solvent, we first show that, due to active stress ...
Callan-Jones, A. C., Voituriez, R.
core +1 more source
The Toxoplasma gondii active serine hydrolase 4 regulates parasite division and intravacuolar parasite architecture [PDF]
, 2018 Hydrolase are enzymes that regulate diverse biological processes, including posttranslational protein modifications. Recent work identified four active serine hydrolases (ASHs) in Toxoplasma gondii as candidate depalmitoylases. However, only TgPPT1 (ASH1)
Amara, Neri +7 more
core +2 more sources
Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals [PDF]
, 2020 Background: The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the promoter and intragenic regions. DNA methylation in the promoter region has been shown to be heavily involved in HIV-1 latency regulation in cultured cells.
De Meyer, Tim +7 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter +17 more
wiley +1 more source