Results 51 to 60 of about 1,974,930 (309)

3D culture of alginate-hyaluronic acid hydrogel supports the stemness of human mesenchymal stem cells

Scientific Reports
The three-dimensional (3D) cell culture system is being employed more frequently to investigate cell engineering and tissue repair due to its close mimicry of in vivo microenvironments.
Amorn Pangjantuk, Palakorn Kaokaen, Phongsakorn Kunhorm, Nipha Chaicharoenaudomrung, Parinya Noisa   +4 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

Adverse outcome pathway-based analysis of liver steatosis in vitro using human liver cell lines

STAR Protocols, 2023
Summary: Here, we present an in vitro test battery to analyze chemicals for their potential to induce liver triglyceride accumulation, a hallmark of liver steatosis.
Mawien Karaca, Kristin Fritsche, Dajana Lichtenstein, Özlem Vural, Katrin Kreuzer, Jimmy Alarcan, Albert Braeuning, Philip Marx-Stoelting, Tewes Tralau   +8 more
doaj   +1 more source

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses. [PDF]

, 2019
A stable latent reservoir for HIV-1 in resting CD4+ T cells is the principal barrier to a cure1-3. Curative strategies that target the reservoir are being tested4,5 and require accurate, scalable reservoir assays.
Antar, Annukka AR, Beg, Subul A, Bender, Alexandra M, Bertagnolli, Lynn N, Blankson, Joel N, Bruner, Katherine M, Bushman, Frederic D, Capoferri, Adam A, Deeks, Steven G, Fray, Emily J, Gregg, John, Ho, Ya-Chi, Jenike, Katharine M, Kufera, Joshua T, Kwon, Kyungyoon J, Laird, Gregory M, Margolick, Joseph B, Nobles, Christopher, Sengupta, Srona, Siliciano, Janet D, Siliciano, Robert F, Simonetti, Francesco R, Timmons, Andrew, Wada, Nikolas, Wang, Zheng, Zhang, Hao   +25 more
core   +1 more source

Long non-coding RNA expression profiling in the NCI60 cancer cell line panel using high-throughput RT-qPCR [PDF]

, 2016
Long non-coding RNAs (lncRNAs) form a new class of RNA molecules implicated in various aspects of protein coding gene expression regulation. To study lncRNAs in cancer, we generated expression profiles for 1707 human lncRNAs in the NCI60 cancer cell line
Derveaux, Stefaan, Hellemans, Jan, Lefever, Steve, Mestdagh, Pieter, Vandesompele, Jo, Volders, Pieter-Jan   +5 more
core   +2 more sources

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Measuring CPT-1-mediated respiration in permeabilized cells and isolated mitochondria

STAR Protocols, 2021
Summary: Carnitine palmitoyltransferase-1 (CPT-1) is a rate-controlling enzyme for long-chain fatty acid oxidation. This manuscript provides protocols for measuring CPT-1-mediated respiration in permeabilized, adherent cell monolayers and mitochondria ...
Krista Yang, Mary T. Doan, Linsey Stiles, Ajit S. Divakaruni   +3 more
doaj   +1 more source

A pilot study evaluating concordance between blood-based and patient-matched tumor molecular testing within pancreatic cancer patients participating in the Know Your Tumor (KYT) initiative [PDF]

, 2016
Recent improvements in next-generation sequencing (NGS) technology have enabled detection of biomarkers in cell-free DNA in blood and may ultimately replace invasive tissue biopsies.
Aberra, Metasebia, Bender, R. Joseph, Brody, Jonathan, Chung, Vincent, Heartwell, Craig, Hendifar, Andrew, Hoos, William A., Madhavan, Subha, Mason, Kimberly, Matrisian, Lynn M., Mikhail, Sam, Petricoin, Emanuel, III, Picozzi, Vincent, Pishvaian, Michael J., Rahib, Lola, Varieur, Katelyn   +15 more
core   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source