Results 41 to 50 of about 1,590,893 (316)

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Stochastic mathematical models of cell proliferation assays

, 2017
Cell proliferation assays are routinely used to study collective cell behaviour, and can be interpreted with mathematical models. In this thesis, we apply a computational Bayesian technique to calibrate stochastic discrete mathematical models of cell ...
Browning, Alexander P.
core   +1 more source

Characterization of the anti-NMDAR1 autoantibodies using cell-based assays.

, 2021
(A) Human NMDAR1 proteins were expressed on HEK293 cells on BIOCHIPs purchased from Euroimmun. Both anti-Human NMDAR1 autoantibody (Euroimmun) and mouse anti-NMDAR1 antibody (BD, diluted at 1:10,000) recognize the NMDAR1 proteins on HEK293 cells in cell ...
Victoria Risbrough (8295138), Susan Powell (8542947), William Yue (11378218), Sorana Caldwell (423258), Xianjin Zhou (182433)   +4 more
core   +1 more source

Thermostability-based binding assays reveal complex interplay of cation, substrate and lipid binding in the bacterial DASS transporter, VcINDY [PDF]

, 2021
The divalent anion sodium symporter (DASS) family of transporters (SLC13 family in humans) are key regulators of metabolic homeostasis, disruption of which results in pro- tection from diabetes and obesity, and inhibition of liver cancer cell ...
Mulligan, Christopher, Sampson, Connor Dereck David, Bellavista, Cristina Fabregas, Stewart, Matthew J   +3 more
core   +1 more source

Adverse outcome pathway-based analysis of liver steatosis in vitro using human liver cell lines

STAR Protocols, 2023
Summary: Here, we present an in vitro test battery to analyze chemicals for their potential to induce liver triglyceride accumulation, a hallmark of liver steatosis.
Mawien Karaca, Kristin Fritsche, Dajana Lichtenstein, Özlem Vural, Katrin Kreuzer, Jimmy Alarcan, Albert Braeuning, Philip Marx-Stoelting, Tewes Tralau   +8 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Measuring CPT-1-mediated respiration in permeabilized cells and isolated mitochondria

STAR Protocols, 2021
Summary: Carnitine palmitoyltransferase-1 (CPT-1) is a rate-controlling enzyme for long-chain fatty acid oxidation. This manuscript provides protocols for measuring CPT-1-mediated respiration in permeabilized, adherent cell monolayers and mitochondria ...
Krista Yang, Mary T. Doan, Linsey Stiles, Ajit S. Divakaruni   +3 more
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Cell-Based Assays for Screening Androgen Receptor Ligands [PDF]

Seminars in Reproductive Medicine, 2015
The androgen receptor (AR, NR3C4) mediates the majority of androgen effects on target cells. The AR is activated following ligand binding that result is enhanced of target gene transcription. Several cell-based model systems have been developed that allow sensitive detection and monitoring of steroids or other compounds with AR bioactivity.
Campana C, PEZZI, Vincenzo, Rainey WE
openaire   +3 more sources

The PPD-specific T-cell clonal response in UK and Malawian subjects following BCG vaccination: a new repertoire evolves over 12 months.

, 2006
Mycobacterium bovis bacille Calmette Guerin vaccination protects against pulmonary tuberculosis in the United Kingdom but not in Malawi. We investigated whether a difference in the clonal T-cell response to BCG vaccination might account for this.
Msiska, GK, Bennett, Andrea A., Fine, Paul E.M., de Lara, CM, Weir, Rosemary E., Ben-Smith, A, Msiska, Glyn K., Bennett, AR, Crampin, Amelia C, Beverley, Peter C.L., Fine, PE, Gorak-Stolinska, Patricia, Weir, RE, Bennett, Andrea R, Fine, Paul EM, Crampin, Amelia C., Ben-Smith, Anne, Lalor, MK, Dockrell, Hazel M., Floyd, Sian, Msiska, Glyn K, Beverley, Peter, de Lara, Catherine M, Beverley, Peter CL, Lalor, Maeve K., Makamo, K, Weir, Rosemary E, Crampin, AC, Gorak-Stolinska, P, Dockrell, HM, Beverley, PC, Lalor, Maeve K, Dockrell, Hazel M, de Lara, Catherine M., Makamo, Kandakuone, Floyd, S   +35 more
core   +1 more source