Results 41 to 50 of about 27,881,538 (305)

Adverse outcome pathway-based analysis of liver steatosis in vitro using human liver cell lines

STAR Protocols, 2023
Summary: Here, we present an in vitro test battery to analyze chemicals for their potential to induce liver triglyceride accumulation, a hallmark of liver steatosis.
Mawien Karaca, Kristin Fritsche, Dajana Lichtenstein, Özlem Vural, Katrin Kreuzer, Jimmy Alarcan, Albert Braeuning, Philip Marx-Stoelting, Tewes Tralau   +8 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Designing personalised cancer treatments [PDF]

, 2013
The concept of personalised medicine for cancer is not new. It arguably began with the attempts by Salmon and Hamburger to produce a viable cellular chemosensitivity assay in the 1970s, and continues to this day.
Ian A. Cree, Cree, Ian A.
core   +1 more source

Measuring CPT-1-mediated respiration in permeabilized cells and isolated mitochondria

STAR Protocols, 2021
Summary: Carnitine palmitoyltransferase-1 (CPT-1) is a rate-controlling enzyme for long-chain fatty acid oxidation. This manuscript provides protocols for measuring CPT-1-mediated respiration in permeabilized, adherent cell monolayers and mitochondria ...
Krista Yang, Mary T. Doan, Linsey Stiles, Ajit S. Divakaruni   +3 more
doaj   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Protocol for in vitro assessment of human monocyte transendothelial migration using a high-throughput live cell imaging system

STAR Protocols, 2023
Summary: In vitro modeling of the different steps of immune cell recruitment is essential to decipher the role of endothelial cells in this process. Here, we present a protocol for the assessment of human monocyte transendothelial migration using a live ...
Ségolène Ladaigue, Vincent Paget, Anne-Charlotte Lefranc, Monica Quitoco, Emilie Bacquer, Fabien Milliat, Olivier Guipaud   +6 more
doaj   +1 more source

Microfluidic System for Automated Cell-Based Assays [PDF]

JALA: Journal of the Association for Laboratory Automation, 2007
Microfluidic cell culture is a promising technology for applications in the drug screening industry. Key benefits include improved biological function, higher-quality cell-based data, reduced reagent consumption, and lower cost. In this work, we demonstrate how a microfluidic cell culture design was adapted to be compatible with the standard 96-well ...
Philip J, Lee, Navid, Ghorashian, Terry A, Gaige, Paul J, Hung   +3 more
openaire   +2 more sources

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Dually Labeled Neurotensin NTS1R Ligands for Probing Radiochemical and Fluorescence-Based Binding Assays [PDF]

The determination of ligand-receptor binding affinities plays a key role in the development process of pharmaceuticals. While the classical radiochemical binding assay uses radioligands, fluorescence-based binding assays require fluorescent probes ...
Gattor, Albert Owusu, Tahk, Maris-Johanna, Heinrich, Markus R., Ertl, Fabian J., Archipowa, Nataliya, Kutta, Roger J., Dijon, Nicola C., Köckenberger, Johannes, Kutta, Roger Jan, Laasfeld, Tõnis, Gmeiner, Peter, Holliday, Nicholas, Gattor, Albert O., Holliday, Nicholas D., Kopanchuk, Sergei, Ertl, Fabian J., Rinken, Ago, Keller, Max, Heinrich, Markus, Veikšina, Santa, Hübner, Harald, Schettler, Franziska, Ertl, Fabian   +22 more
core   +1 more source

Protocol for the use of Oredsson universal replacement medium for cell banking and routine culturing of monolayer and suspension cultures

STAR Protocols
Summary: The Oredsson universal replacement (OUR) medium is the formulation of a universal xeno-free medium designed for the cultivation of human normal and cancer cells in 2D and 3D cultures.
Stina Oredsson, Atena Malakpour-Permlid, Johan Zhu, Tilo Weber   +3 more
doaj   +1 more source