Results 41 to 50 of about 10,893,804 (303)
eLifeAll living systems use an almost identical standard genetic code (SGC), in which 20 amino acids are assigned non-randomly. According to the error minimization theory, amino acids are arranged to minimize the mutational effect on protein function, while ...
Ryota Miyachi, Norikazu Ichihashi
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk +10 more
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Annals of Mechnikov's Institute, 2020 Introduction. Precursor directed biosynthesis is one of the promising approaches to finding new antimicrobial agents and creating next-generation probiotics. L.
O.V Knysh +3 more
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Decentralizing Cell-Free RNA Sensing With the Use of Low-Cost Cell Extracts
Frontiers in Bioengineering and Biotechnology, 2021 Cell-free gene expression systems have emerged as a promising platform for field-deployed biosensing and diagnostics. When combined with programmable toehold switch-based RNA sensors, these systems can be used to detect arbitrary RNAs and freeze-dried ...
Anibal Arce +16 more
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
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A Joint Channel Estimation and Beamforming Separation Principle for Massive MIMO Systems
IEEE Open Journal of the Communications SocietyWe demonstrate that separating beamforming (i.e., downlink precoding and uplink combining) and channel estimation in multi-user MIMO wireless systems incurs no performance loss in terms of well-known and widely applicable achievable ergodic rate bounds ...
Lorenzo Miretti +2 more
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GATS tag system is compatible with biotin labelling methods for protein analysis
Scientific Reports, 2023 Polypeptide tags and biotin labelling technologies are widely used for protein analyses in biochemistry and cell biology. However, many peptide tag epitopes contain lysine residues (or amino acids) that are masked after biotinylation.
Kohdai Yamada +7 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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Cell-free Screening for NOX Inhibitors
Chemistry & Biology, 2012 NOX enzymes are major ROS generators in pathological states and represent a promising pharmacological target. In this issue of Chemistry & Biology, Smith and colleagues developed an original and elegant cell-free assay to identify specific Nox2 inhibitors in a high throughput manner.
Bedard, Karen, Jaquet, Vincent
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BioTechniques, 2012 Escherichia coli-based cell extract is a vital component of inexpensive and high-yielding cell-free protein synthesis reactions. However, effective preparation of E.
Prashanta Shrestha +2 more
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