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Nanogels designed for cell-free nucleic acid sequestration
Nanoscale, 2023A cationic nanogel was designed for scavenging cell-free deoxyribonucleic acid (cfDNA) from chronic wound exudate.
Yuhang Huang +5 more
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Cell-Free Nucleic Acids for Early Prediction of Preeclampsia
Current Hypertension Reports, 2023This review summarizes the potential of cell-free nucleic acids for predicting preeclampsia, contrasts them with other methods, and discusses these findings' relevance to preeclampsia's pathogenesis and care.Recent studies have demonstrated the utility of cell-free nucleic acids in early preeclampsia risk prediction.
Mira N, Moufarrej +2 more
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Cell-free fetal nucleic acids as prenatal biomarkers
Expert Opinion on Medical Diagnostics, 2011Cell-free fetal nucleic acids in maternal plasma or serum have become important tools in the pursuance of new methods for non-invasive prenatal diagnosis, such as the determination of fetal blood groups and fetal gender. During these pioneering explorations, elevations in the concentration of these new-found biological analytes were noted in several ...
Visca, E. +3 more
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Diagnostic developments involving cell-free (circulating) nucleic acids
Clinica Chimica Acta, 2006The detection of circulating nucleic acids has long been explored for the non-invasive diagnosis of a variety of clinical conditions. In earlier studies, detection of circulating DNA has been investigated for the detection of various forms of cancer. Metastasis and recurrence in certain cancer types have been associated with the presence of high levels
Yu-Kwan, Tong, Y M Dennis, Lo
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Cell-free nucleic acids as biomarkers in cancer patients
Nature Reviews Cancer, 2011DNA, mRNA and microRNA are released and circulate in the blood of cancer patients. Changes in the levels of circulating nucleic acids have been associated with tumour burden and malignant progression. In the past decade a wealth of information indicating the potential use of circulating nucleic acids for cancer screening, prognosis and monitoring of ...
Heidi, Schwarzenbach +2 more
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Cell-free Nucleic Acids as Potential Markers for Preeclampsia
Placenta, 2011Preeclampsia is one of the leading causes of maternal and fetal/neonatal mortality and morbidity worldwide. Therefore, widely applicable and affordable tests are needed to make an early diagnosis before the occurrence of the clinical symptoms. Circulating cell-free nucleic acids in plasma and serum are novel biomarkers with promising clinical ...
Hahn, S. +3 more
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Cell-free nucleic acids as biomarkers in dialyzed patients
Journal of Nephrology, 2013In this review, we discuss the origin, possible biological meaning, quantitative and qualitative changes in the concentrations of cell-free nucleic acids in human circulation with regard to renal failure and the process of dialysis. We focus on the inflammatory response and apoptosis known to be in close relationship not only with hemodialysis but also
Marie, Korabecna +4 more
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Diagnostic utility of pleural cell-free nucleic acids in undiagnosed pleural effusions
Clinical Chemistry and Laboratory Medicine (CCLM), 2022Abstract Pleural effusion (PE) is a common sign caused by various disorders. Microbiology, histology and cytology are reference standards for these disorders. However, these diagnostic tools have limitations, including invasiveness, high cost, long turnaround time, and observer-dependent.
Wen Zhao +5 more
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Circulating Cell-Free Nucleic Acids: Promising Biomarkers of Hepatocellular Carcinoma
Seminars in Oncology, 2012Hepatocellular carcinoma (HCC) is considered to be a fatal disease because of its late diagnosis, underlying liver disease, and refractoriness to systemic treatments. Biomarkers with high sensitivity and specificity that are minimally invasive, reproducible, and easily available have important clinical utility for early diagnosis, prognostication, and ...
Jian, Zhou, Ying-Hong, Shi, Jia, Fan
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