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Cell-Free Nucleic Acids for Early Prediction of Preeclampsia
Current Hypertension Reports, 2023This review summarizes the potential of cell-free nucleic acids for predicting preeclampsia, contrasts them with other methods, and discusses these findings' relevance to preeclampsia's pathogenesis and care.Recent studies have demonstrated the utility of cell-free nucleic acids in early preeclampsia risk prediction.
Mira N Moufarrej +2 more
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Cell-free nucleic acids as biomarkers in cancer patients
Nature Reviews Cancer, 2011DNA, mRNA and microRNA are released and circulate in the blood of cancer patients. Changes in the levels of circulating nucleic acids have been associated with tumour burden and malignant progression. In the past decade a wealth of information indicating the potential use of circulating nucleic acids for cancer screening, prognosis and monitoring of ...
Heidi Schwarzenbach +2 more
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Cell-free fetal nucleic acids as prenatal biomarkers
Expert Opinion on Medical Diagnostics, 2011 Cell-free fetal nucleic acids in maternal plasma or serum have become important tools in the pursuance of new methods for non-invasive prenatal diagnosis, such as the determination of fetal blood groups and fetal gender. During these pioneering explorations, elevations in the concentration of these new-found biological analytes were noted in several ...
Visca, E. +3 more
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Cell-free Nucleic Acids as Potential Markers for Preeclampsia
Placenta, 2011 Preeclampsia is one of the leading causes of maternal and fetal/neonatal mortality and morbidity worldwide. Therefore, widely applicable and affordable tests are needed to make an early diagnosis before the occurrence of the clinical symptoms. Circulating cell-free nucleic acids in plasma and serum are novel biomarkers with promising clinical ...
Hahn, S. +3 more
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Biological Role of Cell-Free Nucleic Acids in Cancer: The Theory of Genometastasis
Critical Reviews in Oncogenesis, 2013The phenomenon of cell-free nucleic acids (cfNA) circulating in plasma has opened new areas of research for the study of the pathobiology of many diseases, particularly cancer. The detection, quantitation and qualitative analysis of such cfNA have had an increasing interest and utility for diagnosis and management of many kinds of cancer, at least as ...
Dolores C Garcia-Olmo +1 more
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Diagnostic utility of pleural cell-free nucleic acids in undiagnosed pleural effusions
Clinical Chemistry and Laboratory Medicine, 2022Abstract Pleural effusion (PE) is a common sign caused by various disorders. Microbiology, histology and cytology are reference standards for these disorders. However, these diagnostic tools have limitations, including invasiveness, high cost, long turnaround time, and observer-dependent.
Wen-Qi Zheng, Zhi-De Hu
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Evidence for cell-free nucleic acids as continuously arising endogenous DNA mutagens
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2016There is extensive literature to show that nucleic acids can be taken up by cells under experimental conditions and that foetal DNA can be detected in maternal tissues. The uptaken DNA can integrate into host cell genomes and can be transcribed and translated into proteins. They can also cause chromosomal damage and karyotype alterations.
Naveen Kumar Nair, Indraneel Mittra
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Fetal Cell-Free Nucleic Acids in the Maternal Circulation: New Clinical Applications
Annals of the New York Academy of Sciences, 2004Abstract: Six years after the demonstration of the presence of cell‐free fetal nucleic acids in maternal plasma, perinatal clinical applications continue to expand. The focus of this article is on advances that have occurred since the CNAPS II conference held in Hong Kong in 2001.
Tuangsit Wataganara, Diana W Bianchi
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