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Cell-free nucleic acids as biomarkers in dialyzed patients
Journal of Nephrology, 2013In this review, we discuss the origin, possible biological meaning, quantitative and qualitative changes in the concentrations of cell-free nucleic acids in human circulation with regard to renal failure and the process of dialysis. We focus on the inflammatory response and apoptosis known to be in close relationship not only with hemodialysis but also
Marie, Korabecna +4 more
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Diagnostic utility of pleural cell-free nucleic acids in undiagnosed pleural effusions
Clinical Chemistry and Laboratory Medicine (CCLM), 2022Abstract Pleural effusion (PE) is a common sign caused by various disorders. Microbiology, histology and cytology are reference standards for these disorders. However, these diagnostic tools have limitations, including invasiveness, high cost, long turnaround time, and observer-dependent.
Wen Zhao +5 more
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Circulating Cell-Free Nucleic Acids: Promising Biomarkers of Hepatocellular Carcinoma
Seminars in Oncology, 2012Hepatocellular carcinoma (HCC) is considered to be a fatal disease because of its late diagnosis, underlying liver disease, and refractoriness to systemic treatments. Biomarkers with high sensitivity and specificity that are minimally invasive, reproducible, and easily available have important clinical utility for early diagnosis, prognostication, and ...
Jian, Zhou, Ying-Hong, Shi, Jia, Fan
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Evidence for cell-free nucleic acids as continuously arising endogenous DNA mutagens
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2016There is extensive literature to show that nucleic acids can be taken up by cells under experimental conditions and that foetal DNA can be detected in maternal tissues. The uptaken DNA can integrate into host cell genomes and can be transcribed and translated into proteins. They can also cause chromosomal damage and karyotype alterations.
Ranjan, Basak +2 more
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Cell-free Nucleic Acids as a Non-Invasive Route for Investigating Atherosclerosis
Current Pharmaceutical Design, 2014Metabolic syndrome is directly linked with atherosclerotic burden and cell-free nucleic acids (cf-NA) analysis has recently emerged as a novel research tool in atherosclerosis practice and research. cf-NA are nucleic acids (DNA, mRNA, miRNA, mitochondrial DNA) found in plasma and cell-free fractions of various other biological fluids. They have all the
Darko, Cerne, Jana Lukac, Bajalo
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Isolation and Comparative Study of Cell‐Free Nucleic Acids from Human Urine
Annals of the New York Academy of Sciences, 2006Abstract: Cell‐free nucleic acids (NA) from human urine were investigated. Concentrations of DNA and RNA in the urine of healthy people were independent of gender and were in the range of 6 ng/mL to 50 ng/mL and 24 ng/mL to 140 ng/mL, respectively. DNA fragments of 150–400 bp represent the main part of cell‐free DNA, along with DNA fragments up to 1 ...
Olga E, Bryzgunova +6 more
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Cell free circulating tumor nucleic acids, a revolution in personalized cancer medicine
Critical Reviews in Oncology/Hematology, 2019Innovative diagnostics are becoming an essential component in personalized cancer medicine. These diagnostics are increasingly based on cell-free nucleic acids and membrane vesicles. Isolating and sequencing cell free circulating DNA (cfDNA) in plasma may progressively substitute tumor biopsies.
Kerachian, Mohammad Amin +2 more
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Cell-free Nucleic Acids in Cancer
Clinics in Laboratory Medicine, 2021Liron Barnea Slonim +6 more
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2010
Fragmented DNA and RNA circulate as cell-free nucleic acids in plasma, serum, urine and other body fluids. Access to these molecules for analysis may allow for detection of certain disease states based on a blood sample. In this study the extraction efficiency of a large volume nucleic acid extraction kit for circulating and viral nucleic acids was ...
Martin Horlitz +5 more
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Fragmented DNA and RNA circulate as cell-free nucleic acids in plasma, serum, urine and other body fluids. Access to these molecules for analysis may allow for detection of certain disease states based on a blood sample. In this study the extraction efficiency of a large volume nucleic acid extraction kit for circulating and viral nucleic acids was ...
Martin Horlitz +5 more
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Fetal Cell‐Free Nucleic Acids in the Maternal Circulation: New Clinical Applications
Annals of the New York Academy of Sciences, 2004Abstract: Six years after the demonstration of the presence of cell‐free fetal nucleic acids in maternal plasma, perinatal clinical applications continue to expand. The focus of this article is on advances that have occurred since the CNAPS II conference held in Hong Kong in 2001.
Tuangsit, Wataganara, Diana W, Bianchi
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