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Circulating cell-free nucleic acids as biomarkers in colorectal cancer screening and diagnosis
Expert Review of Molecular Diagnostics, 2016Screening methods for the most frequent diagnosed malignant tumor, colorectal cancer (CRC), have limitations. Circulating cell-free DNA (cfDNA) analysis came into focus as a potential screening test for CRC. Detection of epigenetic and genetic alterations of cfDNA as DNA methylation or DNA mutations and related ribonucleic acids may improve cancer ...
Kinga, Tóth +3 more
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Cell type inference in cell-free nucleic acid liquid biopsy
Nature BiotechnologyCell-free nucleic acid (cfNA) liquid biopsy offers a versatile, noninvasive alternative to needle biopsy procedures for the diagnosis or surveillance of a broad range of diseases and physiological conditions. Although these noninvasive molecular measurements enable diagnostic biomarker discovery, they often lack the cellular resolution afforded by ...
Sevahn K. Vorperian +4 more
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Cell-free Nucleic Acids in Cancer
Clinics in Laboratory Medicine, 2021Liron Barnea Slonim +6 more
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Cell-Free Fetal Nucleic Acid Testing: A Review of the Technology and Its Applications
Obstetrical & Gynecological Survey, 2011Cell-free fetal nucleic acids circulating in the blood of pregnant women afford the opportunity for early, noninvasive prenatal genetic testing. The predominance of admixed maternal genetic material in circulation demands innovative means for identification and analysis of cell-free fetal DNA and RNA.
Lauren C, Sayres, Mildred K, Cho
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Isolation and Comparative Study of Cell‐Free Nucleic Acids from Human Urine
Annals of the New York Academy of Sciences, 2006Abstract: Cell‐free nucleic acids (NA) from human urine were investigated. Concentrations of DNA and RNA in the urine of healthy people were independent of gender and were in the range of 6 ng/mL to 50 ng/mL and 24 ng/mL to 140 ng/mL, respectively. DNA fragments of 150–400 bp represent the main part of cell‐free DNA, along with DNA fragments up to 1 ...
Olga E, Bryzgunova +6 more
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Cell free circulating tumor nucleic acids, a revolution in personalized cancer medicine
Critical Reviews in Oncology/Hematology, 2019Innovative diagnostics are becoming an essential component in personalized cancer medicine. These diagnostics are increasingly based on cell-free nucleic acids and membrane vesicles. Isolating and sequencing cell free circulating DNA (cfDNA) in plasma may progressively substitute tumor biopsies.
Kerachian, Mohammad Amin +2 more
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2010
Fragmented DNA and RNA circulate as cell-free nucleic acids in plasma, serum, urine and other body fluids. Access to these molecules for analysis may allow for detection of certain disease states based on a blood sample. In this study the extraction efficiency of a large volume nucleic acid extraction kit for circulating and viral nucleic acids was ...
Martin Horlitz +5 more
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Fragmented DNA and RNA circulate as cell-free nucleic acids in plasma, serum, urine and other body fluids. Access to these molecules for analysis may allow for detection of certain disease states based on a blood sample. In this study the extraction efficiency of a large volume nucleic acid extraction kit for circulating and viral nucleic acids was ...
Martin Horlitz +5 more
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Circulating tumor cells and cell-free nucleic acids in patients with gynecological malignancies
Virchows Archiv, 2018The ability to detect cancer cells in the blood or in the bone marrow offers invaluable information which potentially impacts early diagnosis, monitoring of treatment, and prognosis. Accessing blood or other body fluids has the additional advantage of being less invasive than biopsy.
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Development of an Effective Method to Enrich Cell-Free Nucleic Acids in Liquid Samples
Clinical LaboratoryWe aimed to establish a method to extract cell-free DNA (cfDNA) from liquid samples by combining protamine solution with nucleic acid extraction reagents.Samples comprised 1 mL EDTA/2K plasma from healthy individuals (n = 22) and 5, 10, 20, and 40 mL K562 cell culture supernatants.
Arizumi, Kikuchi +5 more
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