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Cell free nucleic acids as diagnostic and prognostic marker in leukemia
memo - Magazine of European Medical Oncology, 2017Nucleic acids in circulation, called cell free DNA (cfDNA) and cell free RNA (cfRNA), have recently been analyzed as suitable diagnostic and prognostic markers in cancer. There have also been several reports about the role of this type of marker in leukemia.
Maryam Eini +3 more
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Genomic Approaches to the Analysis of Cell Free Nucleic Acids
2014Recent advances in high throughput DNA sequencing and microarray technologies have revolutionized the field of genomics and also opened up many opportunities for the analysis of cell-free nucleic acids. These genomic approaches have not only provided a more comprehensive portrait of the landscape of cell-free nucleic acids, but also enabled a number of
Wenying Pan, Stephen R. Quake
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Noninvasive prenatal chromosomal aneuploidy detection using plasma cell-free nucleic acid
Expert Review of Obstetrics & Gynecology, 2010It has been shown that by the end of the first trimester of pregnancy, a small but significant portion of DNA extracted from maternal plasma is of fetal origin. This knowledge has been utilized for the development of clinical diagnostic assays that are widely used outside the USA for the minimally invasive prenatal determination of, for example, fetal ...
Dan Handley, David G Peters
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Molecular Detection of Circulating Tumor Cells and Cell-Free Nucleic Acids
2016One of the key roles performed by pathologists is determination of the presence or absence of tumor in clinical samples. This is the basis for most approaches to staging, monitoring response to treatment, and detecting relapse of neoplasia and, as such, is a critical step in determining the course of patient management.
Nirali M. Patel, Karen Kaul
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Circulating tumor cells and cell-free nucleic acids in patients with gynecological malignancies
Virchows Archiv, 2018The ability to detect cancer cells in the blood or in the bone marrow offers invaluable information which potentially impacts early diagnosis, monitoring of treatment, and prognosis. Accessing blood or other body fluids has the additional advantage of being less invasive than biopsy.
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Effects of Molecular Crowding on the Structures, Interactions, and Functions of Nucleic Acids
Chemical Reviews, 2014Shu-Ichi Nakano +2 more
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Isothermal Amplification of Nucleic Acids
Chemical Reviews, 2015Yong-Xi Zhao, Feng Chen, Qian Li
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