Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A Design of Experiments Approach for Enhancing Room Temperature Stability of a Lyophilised and Paper-Based Bacterial Cell-Free System. [PDF]
Bioengineering (Basel)Shivakumar T +4 more
europepmc +1 more source
Isolation and Culture of Bovine Endometrial Epithelial Cells in a Serum-Free Culture System.
, 2001 Hitomi Takahashi +4 more
openalex +2 more sources
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c.
Cell, 1996 X. Liu +4 more
semanticscholar +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A broad spectrum Shigella vaccine based on VirG53-353 multiepitope region produced in a cell-free system. [PDF]
NPJ VaccinesDesalegn G +12 more
europepmc +1 more source
Detection of Human p53 In-Vitro Expressed in a Transcription-Translation Cell-Free System by a Novel Conjugate Based on Cadmium Sulphide Nanoparticles. [PDF]
Nanomaterials (Basel), 2020 Barba-Vicente V +9 more
europepmc +1 more source
Coarse-grained dynamics of protein synthesis in a cell-free system.
Physical Review Letters, 2011 Eyal Karzbrun +3 more
semanticscholar +1 more source
PROTEIN BIOSYNTHESIS BY A CELL-FREE BACTERIAL SYSTEM [PDF]
Proceedings of the National Academy of Sciences, 1958 M, Beljanski, S, Ochoa
openaire +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source