Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Structural insights into lab-coevolved RNA-RBP pairs and applications of synthetic riboswitches in cell-free system. [PDF]
Nucleic Acids ResFukunaga K +7 more
europepmc +1 more source
Improving the reaction mix of a Pichia pastoris cell-free system using a design of experiments approach to minimise experimental effort. [PDF]
Synth Syst Biotechnol, 2020 Spice AJ +3 more
europepmc +1 more source
Documenting System Specifications through OPM Web-Based Graphics/Text
, 2001 The generation of bimodal formal system specification documents that bi-directionally complement graphics from natural language and vice versa through ObjectProcess Methodology (OPM) is presented.
Equivalence The Case +2 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
A cell-free system for functional studies of small membrane proteins. [PDF]
J Biol ChemJiang S +4 more
europepmc +1 more source
Evidence That Phosphorylation of the α-Subunit of eIF2 Does Not Essentially Inhibit mRNA Translation in Wheat Germ Cell-Free System. [PDF]
Front Plant Sci, 2020 Zhigailov AV +8 more
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Expression and Purification of Cytotoxic Human Ribosomal Proteins in Cell-Free Systems
Caleb Konkle +6 more
openalex +1 more source
Construction of a Novel Cell-Free Translation/Glycosylation System
1 Insect cell extract preparation by the nitrogen decompression method for cell-free translation 2 Glycoprotein synthesis in the cell-free translation/glycosylation system derived from insect cells 3 Establishment and characterization of cell-free ...
Tarui, Hiroshi +2 more
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