Results 1 to 10 of about 121,085,656 (267)

Variability in white blood cell count during uncomplicated malaria and implications for parasite density estimation: a WorldWide Antimalarial Resistance Network individual patient data meta-analysis

Malaria Journal, 2023
Background The World Health Organization (WHO) recommends that when peripheral malarial parasitaemia is quantified by thick film microscopy, an actual white blood cell (WBC) count from a concurrently collected blood sample is used in calculations ...
WorldWide Antimalarial Resistance Network White Blood Cell Count in Malaria Study Group
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Adar-mediated A-to-I editing is required for embryonic patterning and innate immune response regulation in zebrafish

Nature Communications, 2022
Additional roles for A-to-I editing of RNA continue to be uncovered. Niescierowicz et al. report prevalent A-to-I editing in the zebrafish transcriptome, and the distinct maternal and zygotic functions of the editing enzyme Adar in embryonic patterning ...
Katarzyna Niescierowicz, Leszek Pryszcz, Cristina Navarrete, Eugeniusz Tralle, Agata Sulej, Karim Abu Nahia, Marta Elżbieta Kasprzyk, Katarzyna Misztal, Abhishek Pateria, Adrianna Pakuła, Matthias Bochtler, Cecilia Winata   +11 more
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Recurrent spontaneous abortion related to balanced translocation of chromosomes: two case reports

Journal of Medical Case Reports, 2021
Background Recurrent spontaneous abortion (RSA) is often idiopathic, but structural chromosomal abnormality is an important nosogenesis. Balanced translocations or inversions can lead to unbalanced gametes depending on the specific recombination and ...
Xue Wan, Linyan Li, Zulin Liu, Zhenhai Fan, Limei Yu   +4 more
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Human Mesenchymal Stem Cells Derived from the Placenta and Chorion Suppress the Proliferation while Enhancing the Migration of Human Breast Cancer Cells

Stem Cells International, 2022
Background. Breast cancer is the most frequently diagnosed malignancy among women, resulting from abnormal proliferation of mammary epithelial cells. The highly vascularized nature of breast tissue leads to a high incidence of breast cancer metastases ...
Sarawut Sirithammajak, Sirikul Manochantr, Chairat Tantrawatpan, Duangrat Tantikanlayaporn, Pakpoom Kheolamai   +4 more
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The decrease of intraflagellar transport impairs sensory perception and metabolism in ageing

Nature Communications, 2021
Sensory perception and metabolic homeostasis are known to deteriorate with ageing, while mechanisms underlying their deterioration remain poorly understood.
Yincong Zhang, Xiaona Zhang, Yumin Dai, Mengjiao Song, Yifei Zhou, Jun Zhou, Xiumin Yan, Yidong Shen   +7 more
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Phase separation of EML4–ALK in firing downstream signaling and promoting lung tumorigenesis

Cell Discovery, 2021
EML4–ALK fusion, observed in about 3%–7% of human lung adenocarcinoma, is one of the most important oncogenic drivers in initiating lung tumorigenesis. However, it still remains largely unknown about how EML4–ALK fusion exactly fires downstream signaling
Zhen Qin, Honghua Sun, Meiting Yue, Xinwen Pan, Liang Chen, Xinhua Feng, Xiumin Yan, Xueliang Zhu, Hongbin Ji   +8 more
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Identification and validation of quantitative trait loci for ascites syndrome in broiler chickens using whole genome resequencing

BMC Genetics, 2020
Background Ascites syndrome is a hypertensive, multifactorial, multigene trait affecting meat-type chickens imposing significant economic losses on the broiler industry.
Alia Parveen, Christa D. Jackson, Shatovisha Dey, Katy Tarrant, Nicholas Anthony, Douglas D. Rhoads   +5 more
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Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis

Cell Death and Disease, 2021
Liver cirrhosis remains major health problem. Despite the progress in diagnosis of asymptomatic early-stage cirrhosis, prognostic biomarkers are needed to identify cirrhotic patients at high risk developing advanced stage disease.
Yuexin Wu, Yuyan Cao, Keren Xu, Yue Zhu, Yuemei Qiao, Yanjun Wu, Jianfeng Chen, Chen Li, Rong Zeng, Gaoxiang Ge   +9 more
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Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation

Signal Transduction and Targeted Therapy, 2023
Lkb1 deficiency confers the Kras-mutant lung cancer with strong plasticity and the potential for adeno-to-squamous transdifferentiation (AST). However, it remains largely unknown how Lkb1 deficiency dynamically regulates AST.
Zhaoyuan Fang, Xiangkun Han, Yueqing Chen, Xinyuan Tong, Yun Xue, Shun Yao, Shijie Tang, Yunjian Pan, Yihua Sun, Xue Wang, Yujuan Jin, Haiquan Chen, Liang Hu, Lijian Hui, Lin Li, Luonan Chen, Hongbin Ji   +16 more
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Transcriptome profile of the sinoatrial ring reveals conserved and novel genetic programs of the zebrafish pacemaker

BMC Genomics, 2021
Background Sinoatrial Node (SAN) is part of the cardiac conduction system, which controls the rhythmic contraction of the vertebrate heart. The SAN consists of a specialized pacemaker cell population that has the potential to generate electrical impulses.
Rashid Minhas, Henry Loeffler-Wirth, Yusra H. Siddiqui, Tomasz Obrębski, Shikha Vashisht, Karim Abu Nahia, Alexandra Paterek, Angelika Brzozowska, Lukasz Bugajski, Katarzyna Piwocka, Vladimir Korzh, Hans Binder, Cecilia Lanny Winata   +12 more
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