Results 31 to 40 of about 121,085,656 (267)

A mutation that blocks integrin α4β7 activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis

BMC Biology, 2020
Background β7 integrins are responsible for the efficient recruitment of lymphocytes from the blood and their retention in gut-associated lymphoid tissues. Integrin α4β7 binds MAdCAM-1, mediating rolling adhesion of lymphocytes on blood vessel walls when
Hailong Zhang, Yajuan Zheng, Youdong Pan, Changdong Lin, Shihui Wang, Zhanjun Yan, Ling Lu, Gaoxiang Ge, Jinsong Li, Yi Arial Zeng, Jianfeng Chen   +10 more
doaj   +1 more source

Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling

Nature Communications, 2017
MAVS is an essential component of the pathogen-sensing machinery, and functions by forming prion-like filaments. Here the authors show that alternatively translated forms of truncated endogenous MAVS can prevent spontaneous aggregation and degradation in
Nan Qi, Yuheng Shi, Rui Zhang, Wenting Zhu, Bofeng Yuan, Xiaoyan Li, Changwan Wang, Xuewu Zhang, Fajian Hou   +8 more
doaj   +1 more source

Single-cell genome-wide association reveals a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus [PDF]

, 2022
During pandemics, individuals exhibit differences in risk and clinical outcomes. Here, we developed single-cell high-throughput human in vitro susceptibility testing (scHi-HOST), a method for rapidly identifying genetic variants that confer resistance ...
Ko, Dennis C., Bergstrom, Emma, Brennan, Richard G, Brennan, Richard G., Jack Anderson, Christopher W. Woods, Erica J. Washington, Chiu, Christopher, Harding, Alfred T., Micah T. McClain, McClain, Micah T., Alfred T. Harding, Schott, Benjamin H, Ko, Dennis C, Gregory, Simon G., Zhu, Xinyu, Bourgeois, Jeffrey S, Gregory, Simon G, McClain, Micah T, Emily R. Ko, Heaton, Nicholas S., Dennis C. Ko, Richard G. Brennan, Zoe Gardener, Paterson, Suzanna, Nicholas S. Heaton, Wang, Liuyang, Washington, Erica J., Woods, Christopher W., Liuyang Wang, Heaton, Nicholas S, Benjamin H. Schott, Schott, Benjamin H., Woods, Christopher W, Thomas W. Burke, Anderson, Jack, Christopher Chiu, Bourgeois, Jeffrey S., Suzanna Paterson, Ko, Emily R, Washington, Erika J, Emma Bergstrom, Xinyu Zhu, Harding, Alfred T, Burke, Thomas W., Jeffrey S. Bourgeois, Gardener, Zoe, Ko, Emily R., Burke, Thomas W, Simon G. Gregory   +49 more
core   +1 more source

Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2

Nature Communications, 2022
Planar cell polarity (PCP) is critical for tissue-wide coordination and successful development. Here Jussila et al. generate a GFP-Vangl2 fusion for live imaging and discover a surprising directionality to the intercellular propagation of cell polarity ...
Maria Jussila, Curtis W. Boswell, Nigel W. Griffiths, Patrick G. Pumputis, Brian Ciruna   +4 more
doaj   +1 more source

α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation

Nature Communications, 2021
Post-translational modifications of tubulins regulate microtubule properties and neural development. Here, the authors report that one such post-translational modification, α-TubK40me3, is required for neuronal polarization and migration by promoting ...
Xuan Xie, Shaogang Wang, Mingyi Li, Lei Diao, Xingyu Pan, Jijun Chen, Weiguo Zou, Xu Zhang, Wenfeng Feng, Lan Bao   +9 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin [PDF]

, 2004
Copyright © 2004 by The American Society for Cell Biology.Ubiquitylation is a necessary step in the endocytosis and lysosomal trafficking of many plasma membrane proteins and can also influence protein trafficking in the biosynthetic pathway.
Murray, Rachael, Murray, RZ, Wood, S., Wood, SA, Wood, Stephen J., Jolly, LA, A. Jolly, Lachlan, A. Wood, Stephen, Jolly, Lachlan, Murray, R., Jolly, L., Z. Murray, Rachael   +11 more
core   +2 more sources

Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila [PDF]

, 2022
Adult stem cells coordinate intrinsic and extrinsic, local and systemic, cues to maintain the proper balance between self-renewal and differentiation. However, the precise mechanisms stem cells use to integrate these signals remain elusive. Here, we show
Southall, Tony D., Tang, Alexander M, Jones, D. Leanne, Stack, Brian J, Brand, Andrea H., Sandall, Sharsti L., Sênos Demarco, Rafael, Southall, Tony D, Jones, D Leanne, Tang, Alexander M., Stack, Brian J., Voog, Justin, Sandall, Sharsti L, Brand, Andrea H, Demarco, Rafael Senos   +14 more
core   +1 more source

Degron models: a toolbox for rapid in vivo depletion of essential proteins regulating mRNA metabolism

Communications Biology
Due to their essentiality, studying proteins involved in fundamental processes in vivo is challenging. PROTAC-based systems offer time-controlled protein depletion, but their characterization in vivo remains limited. Here, with an efficient direct zygote
Wiktor Antczak, Marcin Szpila, Katarzyna Sałas, Patrycja Daszczuk, Vanessa Linke, Marta Miączyńska, Andrzej Dziembowski, Olga Gewartowska   +7 more
doaj   +1 more source

Fibrogranular materials function as organizers to ensure the fidelity of multiciliary assembly

Nature Communications, 2021
Multicilia are complex, and how they achieve accurate assembly is unclear. Here, the authors show that fibrogranular materials condense into spherical cores and function in multicilia formation by tightly associating with deuterosomes and concentrating ...
Huijie Zhao, Qingxia Chen, Fan Li, Lihong Cui, Lele Xie, Qiongping Huang, Xin Liang, Jun Zhou, Xiumin Yan, Xueliang Zhu   +9 more
doaj   +1 more source