Results 51 to 60 of about 121,085,656 (267)

Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome

, 2018
Thousands of cis-elements in genomes are predicted to have vital functions. Although conservation, activity in surrogate assays, polymorphisms, and disease mutations provide functional clues, deletion from endogenous loci constitutes the gold-standard ...
Rajendran Sanalkumar, Jin Soo Kim, Chandler Zuo, Yoon-A Kang, Sunduz Keles, Prithvia Devadas, Duk Hyoung Kim, Emery H. Bresnick, Kyle J. Hewitt, Rajalekshmi Prathibha, Kirby D Johnson, Colin N. Dewey   +11 more
core   +1 more source

Identifiability and privacy in pluripotent stem cell research [PDF]

, 2014
Data sharing is an essential element of research; however, recent scientific and social developments have challenged conventional methods for protecting privacy.
Williams, C, Bredenoord, AL, Rooke, Heather, Isasi, R;Andrews, PW;Baltz, JM;Bredenoord, AL;Burton, P;Chiu, IM;Hull, SC;Jung, JW;Kurtz, A;Lomax, G;Ludwig, T;McDonald, M;Morris, C;Ng, HH;Rooke, H;Sharma, A;Stacey, GN;Williams, C;Zeng, F;Knoppers, BM, Andrews, Peter W., Baltz, Jay M, Sharma, A, Zeng, F, Ludwig, Tenneille, Kurtz, A, Morris, Clive, Baltz, Jay M., Knoppers, Bartha Maria, Ng, HH, Isasi, Rosario, McDonald, M, Kurtz, Andreas, Burton, P, Zeng, Fanyi, Chiu, Ing-Ming, Andrews, Peter W, Morris, C, Jung, J-W, Lomax, Geoffrey, Ng, Huck Hui, Stacey, Glyn N., Burton, Paul, Lomax, G, Bredenoord, Annelien L., Sharma, Alka, Hull, SC, Chiu, I-M, Bredenoord, Annelien L, Andrews, PW, Stacey, GN, McDonald, Michael, Stacey, Glyn N, Jung, Ji-Won, Hull, Sara Chandros, Ludwig, T, Rooke, H, Knoppers, BM, Williams, Clare, Isasi, R, Baltz, JM   +44 more
core   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23

Nature Communications, 2018
Invariant Natural Killer T cells (iNKT) rapidly exert effector functions upon activation, but the mechanisms of their functional maturation remain to be determined.
Yu Xu, Yang Sun, Hao Shen, Yuling Dai, Haifeng Liu, Ronghong Li, Hongdao Zhang, Ligang Wu, Xiaoyan Zhu, Xiaolong Liu   +9 more
doaj   +1 more source

Contributions of HOX genes to cancer hallmarks: Enrichment pathway analysis and review

Tumor Biology, 2020
Homeobox genes function as master regulatory transcription factors during development, and their expression is often altered in cancer. The HOX gene family was initially studied intensively to understand how the expression of each gene was involved in ...
Danielle Barbosa Brotto, Ádamo Davi Diógenes Siena, Isabela Ichihara de Barros, Simone da Costa e Silva Carvalho, Bruna Rodrigues Muys, Lucas Goedert, Cibele Cardoso, Jessica Rodrigues Plaça, Anelisa Ramão, Jeremy Andrew Squire, Luiza Ferreira Araujo, Wilson Araújo da Silva   +11 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages

, 2017
Stem cell engineering and grafting of mesencephalic dopamine (mesDA) neurons is a promising strategy for brain repair in Parkinson's disease (PD). Refinement of differentiation protocols to optimize this approach will require deeper understanding of ...
Perlmann, Thomas,, Storvall, Helena,, Gillberg, L, Perlmann, Thomas., Joodmardi, Eliza, Kirkeby, A, Gillberg, Linda,, Parmar, Malin,, Kirkeby, Agnete, Perlmann, Thomas, Lahti, Laura,, Sandberg, Rickard,, Nolbrant, Sara, Dahl, Lina,, Bjorklund, AK, Kee, N,, Storvall, H, Dahl, L, Kee, Nigel, Lahti, L, Björklund, Åsa K., Volakakis, Nikolaos, Kee, Nigel,, Dahl, Lina, Joodmardi, E, Parmar, Malin, Volakakis, N, Björklund, Åsa K.,, Bjoerklund, Aasa K., Joodmardi, Eliza,, Gillberg, Linda, Lahti, Laura, Storvall, Helena, Volakakis, Nikolaos,, Nolbrant, Sara,, Sandberg, Rickard, Nolbrant, S, Kirkeby, Agnete,   +37 more
core   +1 more source

Largen: A Molecular Regulator of Mammalian Cell Size Control [PDF]

, 2014
Little is known about how mammalian cells maintain cell size homeostasis. We conducted a novel genetic screen to identify cell-size-controlling genes and isolated Largen, the product of a gene (PRR16) that increased cell size upon overexpression in human
Gandin, Valentina, Li, Wanda, Inoue, Satoshi, Itsumi, Momoe, Silvester, Jennifer Liepa, Shahinian, Arda, Wakeham, Andrew, Lapin, Valentina, Mullen, Peter J., Haight, Jillian, Wang, Feng, Mak, Tak W., Yamamoto, Kazuo, Topisirovic, Ivan, McCracken, Susan, Sasaki, Masato, Sonenberg, Nahum, Oo, Yathor D, Elia, Andrew J., Alexandrova, Roumiana, Ikura, Mitsuhiko, Wakutani, Yosuke, Oo, Yathor D.   +22 more
core   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source