Results 61 to 70 of about 121,085,656 (267)

Material Cues as Potent Regulators of Epigenetics and Stem Cell Function [PDF]

, 2015
Biophysical signals act as potent regulators of stem cell function, lineage commitment, and epigenetic status. In recent years, synthetic biomaterials have been used to study a wide range of outside-in signaling events, and it is now well appreciated ...
Whitaker, T, Papathanasiou, P, Stevens, MM, Crowder, SW, Leonardo, V   +4 more
core   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

The PDGF/VEGF Receptor Controls Blood Cell Survival in Drosophila

, 2019
The Drosophila PDGF/VEGF receptor (PVR) has known functions in the guidance of cell migration. We now demonstrate that during embryonic hematopoiesis, PVR has a role in the control of antiapoptotic cell survival.
Brückner, Katja, Luque, Carlos M., Duchek, Peter, Perrimon, Norbert, Kockel, Lutz, Rørth, Pernille   +5 more
core   +1 more source

PI5P Triggers ICAM-1 Degradation in Shigella Infected Cells, Thus Dampening Immune Cell Recruitment [PDF]

, 2016
Shigella flexneri, the pathogen responsible for bacillary dysentery, has evolved multiple strategies to control the inflammatory response. Here, we show that Shigella subverts the subcellular trafficking of the intercellular adhesion molecule-1 (ICAM-1),
Boal, Frédéric, Hélène Tronchère, Tronchére, Héléne,, Puhar, Andrea, Philippe J. Sansonetti, Bernard Payrastre, Kunduzova, Oksana,, Payrastre, Bernard,, Xuereb, Jean-Marie,, Puhar, Andrea,, Oksana Kunduzova, Xuereb, Jean-Marie, Tronchére, Héléne, Payrastre, Bernard, Boal, Frédéric,, Jean-Marie Xuereb, Sansonetti, Philippe J., Frédéric Boal, Sansonetti, Philippe J.,, Kunduzova, Oksana, Andrea Puhar   +20 more
core   +1 more source

Identification of a rare Gli1+ progenitor cell population contributing to liver regeneration during chronic injury

Cell Discovery, 2022
In adults, hepatocytes are mainly replenished from the existing progenitor pools of hepatocytes and cholangiocytes during chronic liver injury. However, it is unclear whether other cell types in addition to classical hepatocytes and cholangiocytes ...
Jiayin Peng, Fei Li, Jia Wang, Chaoxiong Wang, Yiao Jiang, Biao Liu, Juan He, Kai Yuan, Chenyu Pan, Moubin Lin, Bin Zhou, Luonan Chen, Dong Gao, Yun Zhao   +13 more
doaj   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

, 2019
Medulloblastoma (MB), the most frequent malignant childhood brain tumor, can arise from cellular malfunctions during hindbrain development. Here we generate humanized models for Sonic Hedgehog (SHH)-subgroup MB via MYCN overexpression in primary human ...
Sundström, Anders, Čančer, Matko,, Garancher, Alexandra, Weishaupt, Holger, Falk, Anna,, Bergström, Tobias, Wechsler-Reya, Robert J., Tailor, Jignesh, Johansson, Fredrik K.,, Bergström, Tobias,, Sundström, Anders,, Wechsler-Reya, Robert J.,, Čančer, Matko, Holmberg Olausson, Karl, Holmberg Olausson, Karl,, Tailor, Jignesh,, Hutter, Sonja, Hutter, Sonja,, Essand, Magnus, Rosén, Gabriela, Weishaupt, Holger,, Falk, Anna, Johansson, Fredrik K., Rosén, Gabriela,, Essand, Magnus,, Garancher, Alexandra,   +25 more
core   +1 more source

Novel Circulating Tumour Cell-Related Risk Model Indicates Prognosis and Immune Infiltration in Lung Adenocarcinoma

Journal of Immunology Research, 2022
Background. Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer (LC) and one of the leading causes of cancer-related death worldwide. LUAD has a low survival rate owing to tumour invasion and metastasis.
Lu Liang, Yueying Liu, Shiyao Jiang, Jingjing Huang, Hua He, Li Shen, Li Cong, Yiqun Jiang   +7 more
doaj   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

On the mechanical interplay between intra- and inter-synchronization during collective cell migration : a numerical investigation [PDF]

, 2013
Collective cell migration is a fundamental process that takes place during several biological phenomena such as embryogenesis, immunity response, and tumorogenesis, but the mechanisms that regulate it are still unclear.
ALLENA, Rachele, Sharpe, J., AUBRY, Denis, SHARPE, James   +3 more
core   +1 more source