Results 81 to 90 of about 121,085,656 (267)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Autocrine glutamate signaling drives cell competition in Drosophila.

Cell competition is an evolutionarily conserved quality control process that eliminates suboptimal or potentially dangerous cells. Although differential metabolic states act as direct drivers of competition, how these are measured across tissues is not ...
Soares, CC, Maresma, MF, Rizzo, A, Meier, P   +3 more
core   +1 more source

Bending the boundaries: the many facets of endophilin-As from membrane dynamics to disease

Cellular and Molecular Life Sciences
The endophilin-A proteins (EndoAs) are Bin/Amphiphysin/Rvs (BAR) domain proteins with key roles in both clathrin-mediated (CME) and clathrin-independent endocytosis (CIE).
Shiqiang Xu, Emilie Rigaux, Dorian Hène, Henri-François Renard, Louise Thines   +4 more
doaj   +1 more source

Gonadotropin and steroid hormones regulate pluripotent very small embryonic-like stem cells in adult mouse uterine endometrium

Journal of Ovarian Research, 2018
Background Very small embryonic-like stem cells (VSELs) exist in adult organs, express pluripotent markers and have the ability to differentiate into three germ layers in vitro.
Kreema James, Deepa Bhartiya, Ranita Ganguly, Ankita Kaushik, Kavita Gala, Pushpa Singh, S. M. Metkari   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas

, 2021
Ductal cells have been proposed as a source of adult β cell neogenesis, but this has remained controversial. By combining lineage tracing, 3D imaging, and single-cell RNA sequencing (scRNA-seq) approaches, we show that ductal cells contribute to the β ...
Rackham, Chloe, Lambert, C, Evans, Ian, Sancho, Rocio; id_orcid, Messal, Hendrik A., Jones, P, Hubber, Ella-louise, Messal, HA, Lambert, Christopher, Behrens, Axel, Heimberg, Harry, Hubber, E-L, Heimberg, H, Rackham, C, Jones, Peter; id_orcid, Evans, I, Gribben, C, Behrens, A, Gribben, Christopher, Sancho, R   +19 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Intra-lineage plasticity and functional reprogramming maintain natural killer cell repertoire diversity

, 2019
Natural killer (NK) cell repertoires are made up of phenotypically distinct subsets with different functional properties. The molecular programs involved in maintaining NK cell repertoire diversity under homeostatic conditions remain elusive.
Malmberg, K-J, Ask, Eivind Heggernes, Goodridge, Jodie, Lorenz, S, Lorenz, Susanne, Goodridge, JP, Clancy, T, Malmberg, Karl-Johan, Pfefferle, A,, Sohlberg, Ebba, Sohlberg, E,, Jacobs, Benedikt Marcel, Netskar, Herman, Netskar, H, Ask, EH, Pfefferle, Aline, Clancy, Trevor, Jacobs, B   +17 more
core   +1 more source

Indirect regulation of HMGB1 release by gasdermin D

Nature Communications, 2020
HMGB1 is an inflammatory mediator released by a variety of cell types. Here, the authors show that unlike IL-1β, HMGB1 is released non-specifically following cell lysis.
Allen Volchuk, Anna Ye, Leon Chi, Benjamin E. Steinberg, Neil M. Goldenberg   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source