Results 71 to 80 of about 121,085,656 (267)

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

The Diversification of Cell Death and Immunity: Memento Mori.

, 2019
Why do cells have so many ways to die? Why does "cellular suicide" exist at all? In the war against pathogens and rogue cells, organisms developed cellular suicide as a last resort. Fighting an evolutionary arms race, cell death pathways have adapted and
Legrand, AJ, Konstantinou, M, Goode, EF, Meier, P   +3 more
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition

, 2023
Tumor growth is driven by continued cellular growth and proliferation. Cyclin-dependent kinase 7's (CDK7) role in activating mitotic CDKs and global gene expression makes it therefore an attractive target for cancer therapies.
Bertoli, Cosetta, Lauring, Josh, Vuina, Karla, Bertomeu, Thierry, Sava, Georgina, Huard, Caroline, Meneguello, Leticia, Kriston-Vizi, Janos, Maizels, Rory J, Tyers, Mike, de Bruin, Robertus AM, Wilson, Gemma A, Coulombe-Huntington, Jasmin, Ali, Simak   +13 more
core   +1 more source

Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles

Nature Communications
Sarcopenia is an age-related condition characterized by loss of skeletal muscle mass and strength and is associated with increased cancer incidence and mortality, yet how muscle decline promotes tumorigenesis remains unclear.
Kah Yong Goh, Wen Xing Lee, Qian Gou, Sze Mun Choy, Shi Chee Ong, Priya D. Gopal Krishnan, Huaxin Wang, Lewin Raymarc Roldan Turqueza, Qian Hui Tan, Kenon Chua, Shang Li, Jun Nishiyama, Nathan Harmston, Hong-Wen Tang   +13 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Generation and regulation of microtubule network asymmetry to drive cell polarity [PDF]

, 2020
Microtubules control cell architecture by serving as a scaffold for intracellular transport, signaling, and organelle positioning. Microtubules are intrinsically polarized, and their orientation, density, and post-translational modifications both respond
Meiring, Joyce C.M., Sub Cell Biology, Celbiologie, Shneyer, Boris I., Akhmanova, Anna   +4 more
core   +1 more source

EAM conditioning regimen followed by autologous hematopoietic Stem Cell Transplantation for relapsed, refractory and high risk lymphomas

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Hematopoietic Stem Cell Transplant is the  standard  treatment of refractory / recurrent lymphomas, most of conditioning regimens in this cases are BCNU-based as for BEAM & CBV , this agent (BCNU) is well-known for its severe lung toxicity .
Mohamed BEKADJA, Tamim ALSULIMAN, Rachid BOUHASS, Abdessamed ARABI, Mohamed BRAHIMI, Soufi OSMANI, Nabil YAFOUR, Souad TALHI   +7 more
doaj  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis

, 2020
Deregulation of MYC plays an essential role in T cell acute lymphoblastic leukemia (T-ALL), yet the mechanisms underlying its deregulation remain elusive.
Jiang, Jue, Han, Meng, Wang, Yanwu, Zhang, Yingchi, Feng, Hui, Zhu, Xiaofan, Qing, Guoliang, Sun, Yonghua, Wu, Chao, Yue, Ming, Cai, Xiaolian, Jiang, Peng, Wang, Tianci, Li, Peng, Liu, Hudan, Su, Hexiu, Wang, Jingchao, Xiao, Wuhan   +17 more
core   +1 more source