Results 21 to 30 of about 121,085,656 (267)

Cell Competition and its role in the regulation of cell fitness from development to cancer [PDF]

, 2016
Cell competition is a cell fitness-sensing mechanism conserved from insects to mammals that eliminates those cells that, although viable, are less fit than their neighbors. An important implication of cell competition is that cellular fitness is not only
di gregorio, A, Rodriguez, T, Bowling, S
core   +1 more source

Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour [PDF]

, 2011
The mechanism of eukaryotic chemotaxis remains unclear despite intensive study. The most frequently described mechanism acts through attractants causing actin polymerization, in turn leading to pseudopod formation and cell movement.
Haastert, Peter J.M. van,, Peter J M van Haastert, van Haastert, Peter J. M., van Haastert, Peter J.M., Matthew P. Neilson, Douwe M Veltman, Webb, Steven D., Insall, Robert H., Webb, Steven D.,, Neilson, Matthew P.,, Neilson, Matthew P., Matthew P Neilson, Douwe M. Veltman, Peter J. M. van Haastert, Insall, Robert H.,, Steven D Webb, Webb, Steven, Robert H Insall, John A. Mackenzie, Mackenzie, John A.,, John A Mackenzie, Veltman, Douwe M.,, Mackenzie, John A., Veltmahn, Douwe M., Veltman, Douwe M., Steven D. Webb, Robert H. Insall   +26 more
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Identification of Donor Origin and Condition of Transplanted Islets in Situ in the Liver of a Type 1 Diabetic Recipient

Cell Transplantation, 2017
Transplantation of islet allografts into type 1 diabetic recipients usually requires multiple pancreas donors to achieve insulin independence. This adds to the challenges of immunological monitoring of islet transplantation currently relying on surrogate
Cornelis R. Van Der Torren, Jessica S. Suwandi, Dahae Lee, Ernst-Jan T. Van't Wout, Gaby Duinkerken, Godelieve Swings, Arend Mulder, Frans H. J. Claas, Zhidong Ling, Pieter Gillard, Bart Keymeulen, Peter In't Veld, Bart O. Roep   +12 more
doaj   +1 more source

Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer

Breast Cancer Research, 2018
Background Phosphatase and tensin homolog (PTEN) is one of the most frequently inactivated tumor suppressors in breast cancer. While PTEN itself is not considered a druggable target, PTEN synthetic-sick or synthetic-lethal (PTEN-SSL) genes are potential ...
Yew Chung Tang, Szu-Chi Ho, Elisabeth Tan, Alvin Wei Tian Ng, John R. McPherson, Germaine Yen Lin Goh, Bin Tean Teh, Frederic Bard, Steven G. Rozen   +8 more
doaj   +1 more source

Long-read transcriptome sequencing reveals abundant promoter diversity in distinct molecular subtypes of gastric cancer

Genome Biology, 2021
Background Deregulated gene expression is a hallmark of cancer; however, most studies to date have analyzed short-read RNA sequencing data with inherent limitations.
Kie Kyon Huang, Jiawen Huang, Jeanie Kar Leng Wu, Minghui Lee, Su Ting Tay, Vikrant Kumar, Kalpana Ramnarayanan, Nisha Padmanabhan, Chang Xu, Angie Lay Keng Tan, Charlene Chan, Dennis Kappei, Jonathan Göke, Patrick Tan   +13 more
doaj   +1 more source

PI3K-C2 alpha Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation [PDF]

, 2018
Insulin resistance is a syndrome that affects multiple insulin target tissues, each having different biological functions regulated by insulin. A remaining question is to mechanistically explain how an insulin target cell/tissue can be insulin resistant ...
Berggren, PO, Leibiger, IB, Paschen, M, Yunn, NO, Lim, JH, Leibiger, B, Ryu, SH, Moede, T, Pereira, T   +8 more
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The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway [PDF]

, 2009
© 2009 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,.
Jacquier, N, Höfken, T, Lin, Meng, Jacquier, Nicolas, Schneiter, R, Unden, H, Just, Ursula, Just, U, Unden, Heike, Höfken, Thomas, Schneiter, Roger   +10 more
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Two homologous Agr-like quorum-sensing systems cooperatively control adherence, cell morphology, and cell viability properties in Lactobacillus plantarum WCFS1 [PDF]

, 2008
A two-component regulatory system of Lactobacillus plantarum, encoded by genes designated lamK and lamR (hpk10 and rrp10), was studied. The lamK and lamR genes encode proteins which are highly homologous to the quorum-sensing histidine kinase LamC and ...
Vos, W.M., de, Kleerebezem, M., Kunuki, Ryoko, Ingham, C.J., Sturme, Mark, Nakayama, J., Vaughan, Elaine, Kunuki, R., Nakayama, Jiro, Sturme, M.H.J., Fujii, Toshio, Kleerebezem, Michiel, Molenaar, D., Fujii, T., Vaughan, E.E., Ingham, Colin, Beerthuyzen, Marke, Molenaar, Douwe, de Vos, Willem, Molenaar, Douwe; id_orcid, de Vos, W.M., Beerthuyzen, M.M.   +21 more
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MAP4K4 inhibition promotes survival of human stem cell derived cardiomyocyte and reduces infarct size in vivo [PDF]

, 2019
Heart disease is a paramount cause of global death and disability. Although cardiomyocyte death plays a causal role and its suppression would be logical, no clinical counter-measures target the responsible intracellular pathways. Therapeutic progress has
Paiva, MA, Michael, LH, Song, W, Kanayaganam, S, Xie, M, Taffet, GE, Harding, SE, Pavanello, L, Aqil, R, Bellahcene, M, Maifosie, E, Jarvis, A, Wang, SC, Tralau-Stewart, C, Habib, J, Perrior, T, Narasimham, P, Fiedler, Lorna, Newton, G, Golforoush, PA, Noseda, M, Sampson, RD, Bellahcene, Mohamed, Tan, T, Fiedler, LR, Golforoush, Pelin, Jenkins, M, Sano, M, Schneider, MD, Entman, ML, Chapman, K, Faust, D, Tan, T-H, Harding, Sian, Noseda, Michela, Sanmugalingam, D, Schneider, Michael, Stuckey, DJ, Yan, R, Maifoshie, E, Narasimhan, P, Low, CMR, Harada, M   +42 more
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Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer

npj Genomic Medicine, 2023
Somatic PTEN mutations are common and have driver function in some cancer types. However, in colorectal cancers (CRCs), somatic PTEN-inactivating mutations occur at a low frequency (~8–9%), and whether these mutations are actively selected and promote ...
Ilya G. Serebriiskii, Valerii A. Pavlov, Grigorii V. Andrianov, Samuel Litwin, Stanley Basickes, Justin Y. Newberg, Garrett M. Frampton, Joshua E. Meyer, Erica A. Golemis   +8 more
doaj   +1 more source