Results 41 to 50 of about 116,742,798 (255)

Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures

Cell Reports, 2023
Summary: Recent advances in synthetic embryology have opened new avenues for understanding the complex events controlling mammalian peri-implantation development.
Jack-Christophe Cossec, Tatiana Traboulsi, Sébastien Sart, Yann Loe-Mie, Manuel Guthmann, Ivo A. Hendriks, Ilan Theurillat, Michael L. Nielsen, Maria-Elena Torres-Padilla, Charles N. Baroud, Anne Dejean   +10 more
doaj   +1 more source

Case Report: Comparison different response after neoadjuvant chemotherapy of the breast with cell-in-cell—report of two cases

Frontiers in Medicine
Neoadjuvant chemotherapy (NACT) is commonly applied in human epidermal growth factor receptor 2 (HER2)-positive breast cancer to reduce tumor size and increase the likelihood of breast-conserving surgery.
Danhong Zhan, Zhikang Li, Kaiting Yu, Chenxi Wang, Qiang Sun, Ruizhi Wang, Meifang He   +6 more
doaj   +1 more source

Cell hiding in colorectal cancer: correlation with response to chemotherapy in vitro and in vivo

Scientific Reports
Resistance to chemotherapy remains the main challenge for cancer treatment. One of the mechanisms of tumor escape from cytotoxic agents could be the formation of cell-in-cell (CIC) structures, in which the outer cell protects the inner cell from ...
I. Druzhkova, A. Potapov, N. Ignatova, M. Bugrova, I. Shchechkin, M. Lukina, L. Shimolina, E. Kolesnikova, M. Shirmanova, E. Zagaynova   +9 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Single-cell genome-wide association reveals a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus [PDF]

, 2022
During pandemics, individuals exhibit differences in risk and clinical outcomes. Here, we developed single-cell high-throughput human in vitro susceptibility testing (scHi-HOST), a method for rapidly identifying genetic variants that confer resistance ...
Ko, Dennis C., Bergstrom, Emma, Brennan, Richard G, Brennan, Richard G., Jack Anderson, Christopher W. Woods, Erica J. Washington, Chiu, Christopher, Harding, Alfred T., Micah T. McClain, McClain, Micah T., Alfred T. Harding, Schott, Benjamin H, Ko, Dennis C, Gregory, Simon G., Zhu, Xinyu, Bourgeois, Jeffrey S, Gregory, Simon G, McClain, Micah T, Emily R. Ko, Heaton, Nicholas S., Dennis C. Ko, Richard G. Brennan, Zoe Gardener, Paterson, Suzanna, Nicholas S. Heaton, Wang, Liuyang, Washington, Erica J., Woods, Christopher W., Liuyang Wang, Heaton, Nicholas S, Benjamin H. Schott, Schott, Benjamin H., Woods, Christopher W, Thomas W. Burke, Anderson, Jack, Christopher Chiu, Bourgeois, Jeffrey S., Suzanna Paterson, Ko, Emily R, Washington, Erika J, Emma Bergstrom, Xinyu Zhu, Harding, Alfred T, Burke, Thomas W., Jeffrey S. Bourgeois, Gardener, Zoe, Ko, Emily R., Burke, Thomas W, Simon G. Gregory   +49 more
core   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Bacillus subtilis MreB orthologs self-organize into filamentous structures underneath the cell membrane in a heterologous cell system. [PDF]

PLoS ONE, 2011
Actin-like bacterial cytoskeletal element MreB has been shown to be essential for the maintenance of rod cell shape in many bacteria. MreB forms rapidly remodelling helical filaments underneath the cell membrane in Bacillus subtilis and in other ...
Felix Dempwolff, Christian Reimold, Michael Reth, Peter L Graumann   +3 more
doaj   +1 more source

Viral Hijack of Filamentous Surface Structures in Archaea and Bacteria

Viruses, 2021
The bacterial and archaeal cell surface is decorated with filamentous surface structures that are used for different functions, such as motility, DNA exchange and biofilm formation. Viruses hijack these structures and use them to ride to the cell surface
Colin Tittes, Sabine Schwarzer, Tessa E. F. Quax   +2 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin [PDF]

, 2004
Copyright © 2004 by The American Society for Cell Biology.Ubiquitylation is a necessary step in the endocytosis and lysosomal trafficking of many plasma membrane proteins and can also influence protein trafficking in the biosynthetic pathway.
Murray, Rachael, Murray, RZ, Wood, S., Wood, SA, Wood, Stephen J., Jolly, LA, A. Jolly, Lachlan, A. Wood, Stephen, Jolly, Lachlan, Murray, R., Jolly, L., Z. Murray, Rachael   +11 more
core   +2 more sources