Mechanisms and significance of entosis for tumour growth and progression [PDF]
Cell Death DiscoveryTo date, numerous mechanisms have been identified in which one cell engulfs another, resulting in the creation of ‘cell-in-cell’ (CIC) structures, which subsequently cause cell death.
Ksenia Gaptulbarova
exaly +6 more sources
Entosis Is Induced by Glucose Starvation [PDF]
Cell Reports, 2017 Entosis is a mechanism of cell death that involves neighbor cell ingestion. This process occurs in cancers and promotes a form of cell competition, where winner cells engulf and kill losers.
Douglas N Robinson +2 more
exaly +9 more sources
Orai1 is an Entotic Ca 2+ Channel for Non‐Apoptotic Cell Death, Entosis in Cancer Development [PDF]
Advanced Science, 2023 Entosis is a non‐apoptotic cell death process that forms characteristic cell‐in‐cell structures in cancers, killing invading cells. Intracellular Ca2+ dynamics are essential for cellular processes, including actomyosin contractility, migration, and ...
Chan Young Park, Ah Reum Lee
exaly +4 more sources
A bibliometric and visualization analysis of entosis research from 2007 to 2024 [PDF]
Frontiers in OncologyObjectiveIn 2007, entosis was proposed as a form of programmed cell death, distinct from apoptosis. This process involves a living cell (internalized cell) actively invading a neighboring live cell of the same type (host cell), forming a cell-in-cell ...
Xuan Huang
exaly +6 more sources
Entosis: the core mechanism and crosstalk with other cell death programs [PDF]
Experimental and Molecular MedicineCell death pathways play critical roles in organism development and homeostasis as well as in the pathogenesis of various diseases. While studies over the last decade have elucidated numerous different forms of cell death that can eliminate cells in ...
Sung Eun Kim +2 more
exaly +5 more sources
Differential Sensitivity to MEK Inhibitors Highlights Distinct Entosis Mechanisms in BxPC3 and MCF7 Cells [PDF]
CellsEntosis is a form of cell-in-cell interaction observed in epithelial cancers, characterized by the internalization of one cell into another. This process is initiated by cell detachment, cadherin-mediated homotypic adhesion, and the formation of an ...
Paweł Tyrna +4 more
doaj +3 more sources
Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells [PDF]
Cell Death and Disease, 2022 On glucose restriction, epithelial cells can undergo entosis, a cell-in-cell cannibalistic process, to allow considerable withstanding to this metabolic stress.
José C Perales +2 more
exaly +4 more sources
Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma [PDF]
Cell Death and DiseaseEntosis is a process that leads to the formation of cell-in-cell structures commonly found in cancers. Here, we identified entosis in hepatocellular carcinoma and the loss of Rnd3 (also known as RhoE) as an efficient inducer of this mechanism.
Frédéric Saltel +2 more
exaly +3 more sources
Entosis remodels the immune microenvironment of osteosarcoma by regulating macrophage polarization: An integrated study based on multi-omics data and in vitro experiments [PDF]
Translational OncologyBackground: Entosis is a non-apoptotic form of programmed cell death. Its clinical significance and mechanism of immune microenvironment remodeling in osteosarcoma remain poorly understood. Methods: Multi-omics data from TARGET-OS and GEO were integrated
Guoling Huang +3 more
doaj +2 more sources
Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies [PDF]
Frontiers in Oncology, 2023 One of the regulated forms of cell death is the cell-in-cell (CIC) structure, in which a surviving cell is engulfed by another cell, a mechanism that causes the death of the engulfed cell by an adjacent cell.
Kohei Okuyama +5 more
doaj +2 more sources