Mapping Cell-in-Cell Structures in Oral Squamous Cell Carcinoma [PDF]
Cells, 2023 Cell-in-cell (CIC) structures contribute to tumor aggressiveness and poor prognosis in oral squamous cell carcinoma (OSCC). In vitro 3D models may contribute to the understanding of the underlying molecular mechanisms of these events.
Leonardo de Oliveira Siquara da Rocha +4 more
doaj +4 more sources
Subtype-Based Analysis of Cell-in-Cell Structures in Esophageal Squamous Cell Carcinoma [PDF]
Frontiers in Oncology, 2021 Cell-in-cell (CIC) structures are defined as the special structures with one or more cells enclosed inside another one. Increasing data indicated that CIC structures were functional surrogates of complicated cell behaviors and prognosis predictor in ...
Yuqi Wang +18 more
doaj +4 more sources
Subtype-Based Prognostic Analysis of Cell-in-Cell Structures in Early Breast Cancer [PDF]
Frontiers in Oncology, 2019 Though current pathological methods are greatly improved, they provide rather limited functional information. Cell-in-cell structures (CICs), arising from active cell–cell interaction, are functional surrogates of complicated cell behaviors within ...
Xin Zhang +17 more
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Cell-In-Cell Structures in Early Breast Cancer Are Prognostically Valuable [PDF]
Cells, 2022 Cell-in-cell (CIC) structures in breast cancer have so far been studied in a small inhomogeneous patient population, suggesting the prognostic importance of CIC. In the present study, we focused on CIC in early hormone-sensitive breast cancer.
Mareike F. Bauer +10 more
doaj +2 more sources
Classification of Cell-in-Cell Structures: Different Phenomena with Similar Appearance [PDF]
Cells, 2021 A phenomenon known for over 100 years named “cell-in-cell” (CIC) is now undergoing its renaissance, mostly due to modern cell visualization techniques. It is no longer an esoteric process studied by a few cell biologists, as there is increasing evidence ...
Karol Borensztejn +6 more
doaj +2 more sources
Homotypic cell-in-cell structures as an adverse prognostic predictor of hepatocellular carcinoma [PDF]
Frontiers in Oncology, 2022 Hepatocellular carcinoma (HCC) is one of the most common malignant liver tumors. A homotypic cell-in-cell structure (hoCIC) refers to one or more cells internalized into the same type as their neighbors, which predominantly occurs in multiple tumors. The
Ruizhi Wang +6 more
doaj +2 more sources
Tumor malignancy by genetic transfer between cells forming cell-in-cell structures [PDF]
Cell Death and Disease, 2023 Cell-in-cell structures (CICs) refer to a type of unique structure with one or more cells within another one, whose biological outcomes are poorly understood. The present study aims to investigate the effects of CICs formation on tumor progression. Using
Ruizhi Wang +8 more
doaj +2 more sources
Cell-in-Cell Structures in the Liver: A Tale of Four E’s [PDF]
Frontiers in Immunology, 2020 The liver is our largest internal organ and it plays major roles in drug detoxification and immunity, where the ingestion of extracellular material through phagocytosis is a critical pathway. Phagocytosis is the deliberate endocytosis of large particles,
Scott P. Davies +4 more
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Heterotypic cell-in-cell structures between cancer and NK cells are associated with enhanced anticancer drug resistance [PDF]
iScience, 2022 Summary: The heterotypic CIC structures formed of cancer and immune cells have been observed in tumor tissues. We aimed to assess the feasibility of using heterotypic CICs as a functional biomarker to predict NK susceptibility and drug resistance.
Yun-Jeong Choe +18 more
doaj +2 more sources
Progress on Crowding Effect in Cell-like Structures
Membranes, 2022 Several biological macromolecules, such as proteins, nucleic acids, and polysaccharides, occupy about 30% of the space in cells, resulting in a crowded macromolecule environment.
Chao Li +3 more
doaj +3 more sources