Results 11 to 20 of about 116,742,798 (255)

Non-Professional Phagocytosis Increases in Melanoma Cells and Tissues with Increasing E-Cadherin Expression

Current Oncology, 2023
Non-professional phagocytosis in cancer has been increasingly studied in recent decades. In malignant melanoma metastasis, cell-in-cell structures have been described as a sign of cell cannibalism.
Luzie Helene Unseld, Laura S. Hildebrand, Florian Putz, Maike Büttner-Herold, Christoph Daniel, Rainer Fietkau, Luitpold Valentin Distel   +6 more
doaj   +1 more source

Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma [PDF]

, 2021
ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma (ccRCC) aiming to understand the mechanism underpinning therapeutic response.
Schnidrig, D, Sunderland, MW, Ghorani, E, Lingard, K, Rowan, A, Jamal-Hanjani, M, Litchfield, K, Turajlic, S, Becker, PD, Swanton, C, Borg, E, PEACE Consortium, Hatipoglu, E, Mahadeva, U, Xu, H, Hazell, S, Mitchison, M, Green, A, TRACERx Renal Consortium, Reading, JL, Sarker, S, Robert de Massy, M, Nicol, D, TRACERx Renal Consortium,, Falzon, M, López, JI, Edmonds, K, Carlyle, E, Mason, R, Salgado, R, Vasquez, MD, Uddin, I, Au, L, Proctor, I, Yang, WW, Quezada, SA, Spencer, C, Fotiadis, N, Shepherd, STC, Mangwende, M, Dhillon, K, Joshi, K, Lund, T, Byrne, F, Horswell, S, Beattie, G, Moore, DA, PEACE Consortium,, Furness, AJS, Puccio, I, Akarca, A, Thompson, R, Larkin, J, Chain, B, Del Rosario, L, Fendler, A, Pickering, L, Kassiotis, G, Marafioti, T, Attig, J   +59 more
core   +1 more source

Mechanical Ring Interfaces between Adherens Junction and Contractile Actomyosin to Coordinate Entotic Cell-in-Cell Formation

Cell Reports, 2020
Summary: Entosis is a cell-in-cell (CIC)-mediated death program. Contractile actomyosin (CA) and the adherens junction (AJ) are two core elements essential for entotic CIC formation, but the molecular structures interfacing them remain poorly understood.
Manna Wang, Zubiao Niu, Hongquan Qin, Banzhan Ruan, You Zheng, Xiangkai Ning, Songzhi Gu, Lihua Gao, Zhaolie Chen, Xiaoning Wang, Hongyan Huang, Li Ma, Qiang Sun   +12 more
doaj   +1 more source

Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal.

, 2022
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with clear cell renal cell carcinoma.
Raine, K, Yates, LR, Teague, J, Lopez, JI, Gore, M, Rowan, A, Mitchell, TJ, Lynch, AG, Au, L, Stewart, A, Litchfield, K, Turajlic, S, Tarpey, P, Chandra, A, Csabai, I, Swanton, C, Fotiadis, N, Lynch, J, Soultati, A, Challacombe, B, Xu, H, Hazell, S, Stamp, G, Elaidi, R, Horswell, S, Campbell, PJ, Chowdhury, S, Butler, AP, Rudman, S, Wedge, DC, Futreal, PA, Nicol, D, Farmery, JHR, O'Brien, T, Maura, F, McGranahan, N, TRACERx Renal Consortium,, Spain, L, Stewart, GD, Szallasi, Z, Martincorena, I, Stares, M, Fernando, A, Larkin, J, Oudard, S, Pickering, L, Chambers, T, Angelopoulos, N   +47 more
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p57(Kip2) imposes the reserve stem cell state of gastric chief cells

, 2022
Adult stem cells constantly react to local changes to ensure tissue homeostasis. In the main body of the stomach, chief cells produce digestive enzymes; however, upon injury, they undergo rapid proliferation for prompt tissue regeneration.
Ju, Young Seok, Caldwell, Brianna, Wu, Szu-Hsien Sam, Choi, Eunyoung, Stange, Daniel E., Park, JinYoung, Bamford, Aileen-Diane, Kim, Somi, Kim, Jihoon, An, Yohan, Bon-kyoung Koo, Kim, Jong Kyoung, Rocha, Andreia Sofia Batista, Pilat-Carotta, Sandra, Josserand, Manon, Lee, Heetak, Han, Seungmin, Lee, Ji-Hyun, Philpott, Anna, Fink, Juergen, Szep-Bakonyi, Réka, Min, Jimin, Koo, Bon-Kyoung, Lee, Sieun, Simons, Benjamin D.   +24 more
core   +1 more source

Human iPS Cell-Derived Cell Aggregates Exhibited Dermal Papilla Cell Properties in in vitro Three-Dimensional Assemblage Mimicking Hair Follicle Structures

Frontiers in Cell and Developmental Biology, 2021
Current approaches for human hair follicle (HF) regeneration mostly adopt cell-autonomous tissue reassembly in a permissive murine intracorporeal environment. This, together with the limitation in human-derived trichogenic starting materials, potentially
Masahiro Fukuyama, Aki Tsukashima, Momoko Kimishima, Yoshimi Yamazaki, Hideyuki Okano, Manabu Ohyama   +5 more
doaj   +1 more source

Mesenchymal cell invasion requires cooperative regulation of persistent microtubule growth by SLAIN2 and CLASP1 [PDF]

, 2016
Microtubules regulate signaling, trafficking, and cell mechanics, but the respective contribution of these functions to cell morphogenesis and migration in 3D matrices is unclear.
Noordstra, Ivar, Katrukha, Eugene A., Derksen, Patrick W. B., Katrukha, Eugene A, van Amersfoort, Miranda, Ter Hoeve, Natalie D, Celbiologie, Bouchet, Benjamin P, Derksen, Patrick W B, Dogterom, Marileen, Ammon, York-Christoph, Bouchet, Benjamin P., Hodgson, Louis, Sub Cell Biology, Akhmanova, Anna, ter Hoeve, Natalie D.   +15 more
core   +2 more sources

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition [PDF]

, 2021
Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features underpinning CPI sensitization.
Turati, Virginia, Rosenthal, R, Saini, SK, Rosenthal, Rachel, Herrero, Javier, Rowan, A, Turajlic, Samra, Litchfield, K, Guerra-Assunção, José Afonso, Turajlic, S, Hellmann, Matthew D., Swanton, C, Saini, Sunil Kumar, Larkin, James, McGranahan, Nicholas, Reading, JL, Puttick, C, Reading, James L., Swanton, Charles, Thakkar, K, Al Bakir, M, Conde, L, Lim, Emilia, Watkins, TBK, Biswas, D, Enver, Tariq, Puttick, Clare, Turati, V, Litchfield, Kevin, Watkins, Thomas B.K., Hellmann, MD, Rowan, Andrew, Lim, E, Biswas, Dhruva, Van Loo, P, Quezada, SA, Guerra-Assunção, JA, Quezada, Sergio A., Bentham, Robert, Herrero, J, Enver, T, Furness, Andrew J.S., Hadrup, Sine R., Conde, Lucia, Hadrup, SR, Abbosh, C, Lee, Se Hoon, Furness, AJS, Lee, S-H, Al Bakir, Maise, Abbosh, Chris, McGranahan, N, Bentham, R, Larkin, J, Van Loo, Peter, Thakkar, Krupa   +55 more
core   +1 more source

Microtubules in 3D cell motility [PDF]

, 2017
Three-dimensional (3D) cell motility underlies essential processes, such as embryonic development, tissue repair and immune surveillance, and is involved in cancer progression. Although the cytoskeleton is a well-studied regulator of cell migration, most
Sub Cell Biology, Celbiologie, Anna Akhmanova, Bouchet, Benjamin P, Benjamin P. Bouchet, Akhmanova, Anna   +5 more
core   +1 more source

Non-Triple Helical Form of Type IV Collagen α1 Chain

Heliyon, 2015
Type IV collagen with a triple-helical structure composed of three α chains is a major component of basement membrane. Previously, we reported that non-triple helical form of type IV collagen α1 chain (NTHα1(IV)) was isolated from human placenta and the ...
Hiroaki Sugiyama, Kazuhiro Tokunaka, Toshihiko Hayashi, Yasutada Imamura, Makoto Morita, Masayuki Yamato   +5 more
doaj   +1 more source