Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfment
iScience, 2022 Summary: Entosis is a cell competition process during which tumor cells engulf other tumor cells. It is initiated by metabolic stress or by loss of matrix adhesion, and it provides the winning cell with resources derived from the internalized cell. Using
Mariel F. Schwietzer +8 more
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Fluorescence Time-lapse Imaging of Entosis Using Tetramethylrhodamine Methyl Ester Staining
Bio-Protocol, 2022 Entosis is a process where a living cell launches an invasion into another living cell’s cytoplasm. These inner cells can survive inside outer cells for a long period of time, can undergo cell division, or can be released.
Emir Bozkurt +2 more
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Classification of Cell-in-Cell Structures: Different Phenomena with Similar Appearance
Cells, 2021 A phenomenon known for over 100 years named “cell-in-cell” (CIC) is now undergoing its renaissance, mostly due to modern cell visualization techniques. It is no longer an esoteric process studied by a few cell biologists, as there is increasing evidence ...
Karol Borensztejn +6 more
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p53-dependent elimination of aneuploid mitotic offspring by entosis [PDF]
Cell Death & Differentiation, 2020 Entosis was proposed to promote aneuploidy and genome instability by cell-in-cell mediated engulfment in tumor cells. We reported here, in epithelial cells, that entosis coupled with mitotic arrest functions to counteract genome instability by targeting aneuploid mitotic progenies for engulfment and elimination.
Jianqing Liang +19 more
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Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma [PDF]
Modern Pathology, 2020 Entosis is a type of regulated cell death that promotes cancer cell competition. Though several studies have revealed the molecular mechanisms that govern entosis, the clinical and genetic correlates of entosis in human tumors is less well understood. Here we reviewed entotic cell-in-cell (CIC) patterns in a large single institution sequencing cohort ...
Akimasa Hayashi +12 more
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Cell-in-Cell Events in Oral Squamous Cell Carcinoma
Frontiers in Oncology, 2022 For over a century, cells within other cells have been detected by pathologists as common histopathological findings in tumors, being generally identified as “cell-in-cell” structures.
Leonardo de Oliveira Siquara da Rocha +8 more
doaj +1 more source
Mitosis can drive cell cannibalism through entosis. [PDF]
, 2019 Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in human epithelial cells, driven by mitosis.
core +2 more sources
LncRNAs and regulated cell death in tumor cells
Frontiers in Oncology, 2023 Regulated Cell Death (RCD) is a mode of cell death that occurs through drug or genetic intervention. The regulation of RCDs is one of the significant reasons for the long survival time of tumor cells and poor prognosis of patients.
Yingying Wu +4 more
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The lysophosphatidic acid-regulated signal transduction network in ovarian cancer cells and its role in actomyosin dynamics, cell migration and entosis. [PDF]
Theranostics, 2023 Lysophosphatidic acid (LPA) species accumulate in the ascites of ovarian high-grade serous cancer (HGSC) and are associated with short relapse-free survival. LPA is known to support metastatic spread of cancer cells by activating a multitude of signaling
Ojasalu K +11 more
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Distinct Types of Cell Death and the Implication in Diabetic Cardiomyopathy
Frontiers in Pharmacology, 2020 Diabetic cardiomyopathy (DCM) is a chronic complication of diabetes mellitus, characterized by abnormalities of myocardial structure and function. Researches on the models of type 1 and type 2 diabetes mellitus as well as the application of genetic ...
Yun Chen +7 more
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