Results 21 to 30 of about 1,391 (151)

Entosis Allows Timely Elimination of the Luminal Epithelial Barrier for Embryo Implantation [PDF]

Cell Reports, 2015
During implantation, uterine luminal epithelial (LE) cells first interact with the blastocyst trophectoderm. Within 30 hr after the initiation of attachment, LE cells surrounding the blastocyst in the implantation chamber (crypt) disappear, allowing ...
Yingju Li, Xiaofei Sun, Sudhansu K. Dey
doaj   +2 more sources

Entosis Acts as a Novel Way within Sertoli Cells to Eliminate Spermatozoa in Seminiferous Tubule [PDF]

Frontiers in Physiology, 2017
The present study was designed to investigate the hypothesis that in vivo entosis is a novel pathway for eliminating spermatozoa in the seminiferous tubules (ST) during hibernation of the Chinese soft-shelled turtle.
Nisar Ahmed, Nisar Ahmed, Ping Yang, Yufei Huang, Hong Chen, Tengfei Liu, Lingling Wang, Fazul Nabi, Yi Liu, Qiusheng Chen   +9 more
doaj   +2 more sources

Identification and analysis of diverse cell death patterns in osteomyelitis via microarray-based transcriptome profiling and clinical data [PDF]

Frontiers in Immunology
BackgroundOsteomyelitis (OM) is a debilitating infectious disease characterized by inflammation of the bone and bone marrow. Emerging evidence suggests that multiple forms of programmed cell death (PCD) contribute to its pathogenesis.
Tianxuan Feng, Tianxuan Feng, Peisheng Chen, Fengfei Lin, Fengfei Lin   +4 more
doaj   +2 more sources

A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion [PDF]

Cell, 2007
SummaryEpithelial cells require attachment to extracellular matrix (ECM) to suppress an apoptotic cell death program termed anoikis. Here we describe a nonapoptotic cell death program in matrix-detached cells that is initiated by a previously ...
Schnitt, Stuart J., Brugge, Joan S., Mouneimne, Ghassan, Normand, Guillaume, Cibas, Edmund S., Mailleux, Arnaud A., Overholtzer, Michael, King, Randall W.   +7 more
core   +4 more sources

Exploring cell death pathways in oral cancer: mechanisms, therapeutic strategies, and future perspectives [PDF]

Discover Oncology
Oral squamous cell carcinoma (OSCC) represents a significant global health challenge, characterized by aggressive progression and poor therapeutic response despite advances in treatment modalities. This review provides a comprehensive analysis of diverse
Chenyi Zhao
doaj   +2 more sources

Morphological and functional analysis of colorectal cancer cell lines in 2D and 3D culture models [PDF]

Scientific Reports
The epithelial and mesenchymal features of colorectal adenocarcinoma (CRAC) cell lines were compared in two-dimensional (2D) and three-dimensional (3D) cultures.
Seiichi Shinji, Yutaro Ogawa, Takeshi Yamada, Akihisa Matsuda, Kay Uehara, Yasuyuki Yokoyama, Goro Takahashi, Takuma Iwai, Toshimitsu Miyasaka, Shintaro Kanaka, Koki Hayashi, Yuuki Shichi, Masakazu Fujiwara, Kimimasa Takahashi, Tomio Arai, Toshiyuki Ishiwata, Hiroshi Yoshida   +16 more
doaj   +2 more sources

Cell hiding in colorectal cancer: correlation with response to chemotherapy in vitro and in vivo [PDF]

Scientific Reports
Resistance to chemotherapy remains the main challenge for cancer treatment. One of the mechanisms of tumor escape from cytotoxic agents could be the formation of cell-in-cell (CIC) structures, in which the outer cell protects the inner cell from ...
I. Druzhkova, A. Potapov, N. Ignatova, M. Bugrova, I. Shchechkin, M. Lukina, L. Shimolina, E. Kolesnikova, M. Shirmanova, E. Zagaynova   +9 more
doaj   +2 more sources

The Multifaceted Role of Pyroptosis: Molecular Mechanisms, Crosstalk with Other Cell Death Pathways, and Therapeutic Implications. [PDF]

MedComm (2020)
Pyroptosis maintains immune homeostasis by eliminating damaged or infected cells, but its dysregulation promotes inflammation and cancer progression. The diagram illustrates key activation pathways, links with other programmed cell deaths, and cancer‐specific effects, enhancing its dual protective and pathogenic roles.
Boaru DL, De Castro-Martinez P, Garcia-Montero C, Fraile-Martinez O, Alhaddadin MNM, Barrena-Blázquez S, Lopez-Gonzalez L, Fernández CT, Alvarado-Hurtado R, Giménez TR, Lasa-Unzúe I, Alonso MD, Gutiérrez-Calvo A, Saez MA, Cobo-Prieto D, Saz JV, Alvarez-Mon M, Diaz-Pedrero R, Ortega MA.   +18 more
europepmc   +2 more sources

Programmed Cell Death in Cancer. [PDF]

MedComm (2020)
Cancer is one of the most common and lethal diseases globally, with programmed cell death (PCD) playing a pivotal role in its pathogenesis and treatment. This comprehensive review covers the origin, developmental trajectory, and mechanisms of various PCDs, as well as their molecular connections with cancers. Latest studies have increasingly highlighted
Wei Y, Hankey W, Xu D, Yuan F.
europepmc   +2 more sources

ROCK signaling is involved in the entosis of both nonepithelial and epithelial tumors, whereas N‑cadherin is involved in the entosis of nonepithelial tumors. [PDF]

Exp Ther Med
Entosis is a cell-in-cell phenomenon wherein cells detaching from the extracellular matrix are internalized by a neighboring cell. The present study examined whether entosis, which is observed in epithelial cells, also occurs in nonepithelial cells. The present study used the MCF-7 breast cancer cell line as a positive control for entosis and compared ...
Oi M, Kushibiki R, Kanehira Y, Nishijima Y, Kobayashi S, Saio M.   +5 more
europepmc   +3 more sources