Results 121 to 130 of about 142,957 (305)

Functional Peptide-Based Biomaterials for Pharmaceutical Application: Sequences, Mechanisms, and Optimization Strategies

Journal of Functional Biomaterials
Peptide-based biomaterials have emerged as versatile tools for pharmaceutical drug delivery due to their biocompatibility and tunable sequences, yet a comprehensive overview of their categories, mechanisms, and optimization strategies remains lacking to ...
Dedong Yu, Nari Han, Hyejeong Son, Sun Jo Kim, Seho Kweon   +4 more
doaj   +1 more source

Cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide

, 2021
The present disclosure relates to novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide, and methods to make and use the novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating ...
Chmielewski, Jean, Seleem, Mohamed N.
core  

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

Local Administration of a Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Inflammatory Pain in Rats

Journal of Pharmacological Sciences, 2010
Novel agents that inhibit nerve growth factor signaling are required for the treatment of inflammatory pain. The present study investigated the effect of local administration of inhibitory peptide of TrkA (IPTRK3), a synthetic cell-penetrating peptide ...
Koyo Ueda, Munetaka Hirose, Eri Murata, Mayumi Takatori, Masashi Ueda, Hiroshi Ikeda, Kenji Shigemi   +6 more
doaj   +1 more source

Transportan-derived cell-penetrating peptide delivers siRNA to inhibit replication of influenza virus in vivo

, 2019
Cuiling Zhang,1 Weigang Ren,1 Qingxin Liu,2 Zhikai Tan,3 Junwei Li,1 Chunyi Tong3 1College of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, People’s Republic of China; 2Jiangsu Vocational College of Agriculture and Forestry,
Ren W, Tong C, Li J, Tan Z, Liu Q, Zhang C   +5 more
core  

Cell-Penetrating Peptide Conjugated SERS Nanosensor for in Situ Intracellular pH Imaging of Single Living Cells during Cell Cycle

, 2019
Intracellular pH is an important modulator of cell functions, and its subtle change may dramatically affect the cellular activities and cause diseases. A reliable imaging of the intracellular pH is still a great challenge.
Xiao-Shan Zheng, Xin Wang, Bin Ren, Xiao-Shan Zheng (1645504), Bin Ren (352410), Cheng Zong (483204), Xin Wang (91924), Cheng Zong   +7 more
core   +1 more source

Development of Nanoflare Nanosensors for Monitoring Cellular Insulin mRNA in Beta Cells and Islets

Advanced Materials Technologies, EarlyView.
This study presents the design and application of In2‐NF probes for detecting insulin mRNA in beta cells and islets. Using spherical nucleic acid‐coated gold nanoparticles, the probes offer strong fluorescent signals upon hybridization. Their performance is validated across 2D and 3D cultures and rat islets, demonstrating sensitive, real‐time mRNA ...
Yana Hu, Qizheng Zhang, Tianli Hu, Juewen Liu, Hongxing Fu, Xin Zhao, Zijiang Yang, Chenjie Xu   +7 more
wiley   +1 more source

A cell-penetrating bispecific antibody suppresses hepatitis B virus replication and secretion

Virus Research
Hepatitis B virus (HBV) represents one of the major pathogenic factor that leads to chronic liver diseases and the development of hepatocellular carcinoma (HCC). The currently approved anti-HBV drugs cannot eradicate the virus or block the development of
Chongwei Xie, Bing Zhou, Da Yao, Xin Wang, Lihong Zhong, Chuanghua Qiu, Junfang Zhang   +6 more
doaj   +1 more source

Peptide aptamers define distinct EB1- and EB3-binding motifs and interfere with microtubule dynamics [PDF]

, 2014
EB1 is a conserved protein that plays a central role in regulating microtubule dynamics and organisation. It binds directly to microtubule plus ends and recruits other plus end localising proteins.
Warbrick, Emma, Ohkura, Hiroyuki, Lesniewska, Karolina   +2 more
core   +1 more source

Modulus‐Switchable Miniature Robots for Biomedical Applications: A Review

Advanced Robotics Research, EarlyView.
Materials, robot designs, proof‐of‐concept functions, and biomedical applications of modulus‐switchable miniature robots. Miniature soft robots have shown great potential in biomedical applications due to their excellent controllability and suitable mechanical properties in biological environments.
Chunyun Wei, Yibin Wang, Jiangfan Yu
wiley   +1 more source