Results 111 to 120 of about 142,957 (305)

Synthesis and study of cell-penetrating peptide-modified gold nanoparticles

, 2018
Félix Boussoufi,1 Sandra M Navarro Gallón,2 Run Chang,3 Thomas Jay Webster3 1Department of High Performance Materials, Sigma Clermont, Clermont-Ferrand, France; 2Biotechnology Group, Faculty of Exact and Natural Sciences, Universidad de ...
Boussoufi F, Chang R, Navarro Gallón SM, Webster TJ   +3 more
core  

Affinity‐Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics

Advanced Healthcare Materials, EarlyView.
Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He, Nicholas L. Fletcher, Gayathri R. Ediriweera, Yifei Zhu, James Humphries, Christopher B. Howard, Jiazheng Wang, Craig A. Bell, Kristian Kempe, Kristofer J. Thurecht   +9 more
wiley   +1 more source

D-Maurocalcine, a pharmacologically inert efficient cell-penetrating peptide analogue.: Cell Penetrating D-Maurocalcine Peptide

, 2010
International audienceMaurocalcine has been the first demonstrated animal toxin acting as a cell-penetrating peptide. Although it possesses competitive advantages, its use as a cell-penetrating peptide (CPP) requires that analogues be developed that lack
Alphonse, Sébastien, Douzi, Badreddine, Ronjat, Michel, Kaouthar Dridi, Michel De Waard, Hicham Bichraoui, Sebastien Alphonse, Badreddine Douzi, de Waard, Michel, Cathy Poillot, Michel Ronjat, Poillot, Cathy, Pêcher, Julien, Dridi, Kaouthar, Bichraoui, Hicham, Darbon, Hervé, Hervé Darbon, Julien Pêcher   +17 more
core   +1 more source

Cyclic, Cell-Penetrating Peptides Tailor-Made for the Creation of Peptide Libraries with Intrinsic Cell Permeability

, 2020
The discovery of high-affinity peptides to many intracellular targets has become feasible through the development of diverse macrocyclic peptide libraries. But lack of cell permeability is a key feature hampering the use of these peptides as therapeutics.
Koushambi, Mitra, Matthew, Hartman, Anthony, Le, Nicolas A., Abrigo, Kaylee, Newcomb, Kara, Dods   +5 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Cell Penetrating Capacity and Internalization Mechanisms Used by the Synthetic Peptide CIGB-552 and Its Relationship with Tumor Cell Line Sensitivity

Molecules, 2018
CIGB-552 is a twenty-amino-acid novel synthetic peptide that has proven to be effective in reducing tumor size and increasing lifespan in tumor-bearing mice. Such capability is conferred by its cell-penetrating peptide character, which allows it to enter
Soledad Astrada, Julio Raúl Fernández Massó, Maribel G. Vallespí, Mariela Bollati-Fogolín   +3 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Synthesis, Structural and Biological Analysis of Organized Biomimetic Systems

, 2010
As a part of a program for foldamer design two β-turn mimetics (3S)-amino-5-(carboxylmethyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one or DBT and 2-aminomethyl-phenyl-acetic acid or AMPA were selected as frameworks from a molecular modeling study for ...
Lubomir, Vezenkov
core  

Elastin-Derived VGVAPG Fragment Decorated Cell-Penetrating Peptide with Improved Gene Delivery Efficacy

, 2023
Cell-penetrating peptides (CPPs) are attractive non-viral gene delivery vectors due to their high transfection capacity and safety. Previously, we have shown that cell-penetrating peptide RALA can be a promising gene delivery vector for chronic wound ...
Wen-Juan Shen, Xiao-Jun Xu, Biao Jin, Le Fu, Yu Liu, Xiao-Bo Wang, Yong-Bin Ye, Le-Ping Yan, Yun-Sheng Xu, Fang-Ping Li, Chun Tang, Gang Wu, Chun-Fei Wang, Duo-Mei Tian   +13 more
core   +1 more source

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source