Results 91 to 100 of about 142,957 (305)
Advanced Functional Materials, EarlyView.A molecular shielding strategy to convert “protein‐sticky” and “non‐tumor specific” clinical ICG dye, into a “low protein binding” and “tumor‐targeting” dye with prolonged blood circulation and renal clearance is described. These shielded ICGs demonstrate strong tumor accumulation and optimal tissue clearance, resulting in high tumor‐to‐background ...
Li Xiang +9 more
wiley +1 more source
Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides. [PDF]
The Journal of biological chemistry, 2011 Cell-penetrating peptides can translocate across the plasma membrane of living cells and thus are potentially useful agents in drug delivery applications. Disulfide-rich cyclic peptides also have promise in drug design because of their exceptional stability, but to date only one cyclic peptide has been reported to penetrate cells, the Momordica ...
Cascales, Laura +6 more
openaire +3 more sources
CPPpred: prediction of cell penetrating peptides [PDF]
Bioinformatics, 2013 Abstract Summary: Cell penetrating peptides (CPPs) are attracting much attention as a means of overcoming the inherently poor cellular uptake of various bioactive molecules. Here, we introduce CPPpred, a web server for the prediction of CPPs using a N-to-1 neural network.
Thérèse A. Holton +3 more
openaire +4 more sources
Cell-Penetrating Cross‑β Peptide Assemblies with Controlled Biodegradable Properties
, 2016 Although self-assembled peptide nanostructures (SPNs) have shown potential as promising biomaterials, there is a potential problem associated with the extremely slow hydrolysis rate of amide bonds.
Yong-beom Lim (1718119) +2 more
core +1 more source
Cyclical, Cell-Penetrating, Peptide-Protein Fusions [PDF]
, 2017 The expression of recombinant proteins often exploits amino acid motifs that can provide unique properties for recognition, post-translational modification, binding capacity, and translocation potential.
Kerwin, John Forbes
core +1 more source
Advanced Functional Materials, EarlyView.We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins +9 more
wiley +1 more source
Hybrid peptides inspired by the RWQWRWQWR sequence inhibit cervical cancer cells growth in vitro [PDF]
Exploration of Drug ScienceAim: The aim of this research was to generate new peptide molecules with cytotoxic activity against cervical cancer that can become effective in mitigating the impact of the disease and preventing its progression.
Natalia Ardila-Chantré +7 more
doaj +1 more source
Specific targeting of caspase-9/PP2A interaction as potential new anti-cancer therapy. [PDF]
PLoS ONE, 2013 PURPOSE: PP2A is a serine/threonine phosphatase critical to physiological processes, including apoptosis. Cell penetrating peptides are molecules that can translocate into cells without causing membrane damage.
Issam Arrouss +12 more
doaj +1 more source
Human protein 53 derived cell penetrating peptides
, 2012 Tumor suppressor protein 53 plays an important role in the initiation of cell cycle arrest and apoptosis. Being highly mutated in several different cancer types, p53 is a good target for anticancer therapeutics.
Eriste, Elo +3 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng +16 more
wiley +1 more source