Results 161 to 170 of about 142,957 (305)

Bismuth-Cyclized Cell-Penetrating Peptides

Molecular Pharmaceutics
Intracellular delivery of biological cargos, which would yield new research tools and novel therapeutics, remains an active area of research. A convenient and potentially general approach involves the conjugation of a cell-penetrating peptide to a cargo of interest. However, linear CPPs lack sufficient cytosolic entry efficiency and metabolic stability,
Jeremy L. Ritchey, Lindsi Filippi, Davis Ballard, Dehua Pei   +3 more
openaire   +2 more sources

Cell-penetrating peptide conjugates of gambogic acid enhance the antitumor effect on human bladder cancer EJ cells through ROS-mediated apoptosis

, 2018
Lei Lyu,1,* Lu-qi Huang,2,* Tao Huang,1 Wei Xiang,1 Jing-dong Yuan,1 Chuan-hua Zhang1 1Department of Urology, Wuhan No 1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China ...
Lyu L, Huang T, Huang LQ, Yuan JD, Xiang W, Zhang CH   +5 more
core  

Cell penetrating peptides for the decoration of gold nanoparticles

, 2023
openABSTRACT I peptidi che attraversano la membrana cellulare, “cell-penetrating peptides (CPP’s)”, sono molto promettenti per il trattamento di varie malattie.
DEL BIANCO, ALESSANDRO
core  

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Cell penetrating peptide-modified nanoparticles for tumor targeted imaging and synergistic effect of sonodynamic/HIFU therapy [Corrigendum]

International Journal of Nanomedicine, 2019
Li Y, Hao L, Liu F, et al. Int J Nanomedicine. 2019;14:5875–5894.The authors have advised that affiliation 1 for this paper was presented incorrectly as it was split into two affiliations and this was not corrected before the paper was published ...
Li Y, Hao L, Liu F, Yin L, Yan S, Zhao H, Ding X, Guo Y, Cao Y, Li P, Wang Z, Ran H, Sun Y   +12 more
doaj  

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

PepFect14, a Versatile Cell-Penetrating Peptide

, 2020
Cell-penetrating peptides have been discovered almost three decades ago and there are, nowadays, thousands of available sequences. They offer multiple applications in the field of drug delivery as they are able to carry therapeutic macromolecules across ...
Gestin, Maxime
core  

Therapeutic applications of the cell-penetrating HIV-1 Tat peptide

, 2015
Over the past decades, many new therapeutic approaches have been developed for several conditions, including neurodegenerative diseases. However, efficient biodistribution and delivery at biological target sites are hampered by the presence of cell and ...
M. Rizzuti, C. Zanetta, A. Ramirez, Mafalda Rizzuti, Monica Nizzardo, Chiara Zanetta, S. Corti, Agnese Ramirez, Stefania Corti, M. Nizzardo   +9 more
core   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source