Results 171 to 180 of about 5,340,670 (292)

Novel BUF2-magnetite nanobioconjugates with cell-penetrating abilities

, 2018
Monica Cuellar,1 Javier Cifuentes,1 Jessica Perez,1 Alejandra Suarez-Arnedo,1 Julian A Serna,1 Helena Groot,2 Carolina Muñoz-Camargo,1 Juan C Cruz1 1Department of Biomedical Engineering, Universidad de los Andes, Bogotá, Colombia; 2Human ...
Suarez-Arnedo A, Cuellar M, Groot H, Muñoz-Camargo C, Cruz JC, Cifuentes J, Perez J, Serna JA   +7 more
core  

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Correction to "In Vivo Interrogation of Cell-Penetrating Peptide Function: Accumulation in Tumors and the Potential as a Specific PET Probe". [PDF]

Bioconjug Chem
Si Z, Tian L, Zhou H, Lin J, Zhou J.
europepmc   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

RMAD1, a Novel Cell-Penetrating Peptide Derived from ADARB2: Preclinical Insights into Antigen Uptake and T Cell Activation. [PDF]

Int J Biol Sci
Lim C, Park C, Song EC, Shin Y, Kim WK, Park YJ, Youn H, Ham C, Kim SB, Cho S.   +9 more
europepmc   +1 more source

Boronic acid-modified cell-penetrating peptide exhibits superior performance over natural TAT peptide

BORONIC ACID-MODIFIED CELL-PENETRATING PEPTIDE EXHIBITS SUPERIOR PERFORMANCE OVER NATURAL TAT PEPTIDE Boronic acid-modified cell-penetrating peptide exhibits superior performance over natural TAT peptide / Ghosh, Pritam (Rights reserved) (-
Ghosh, Pritam
core  

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Optimizing delivery of an anti-cytomegalovirus inhibitory peptide using a cell-penetrating peptide. [PDF]

J Gen Virol
Beeton K, Haskell JP, Mitra D, Taylor EB, Bidwell GL.   +4 more
europepmc   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source