Results 231 to 240 of about 5,601,044 (283)

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

Corrigendum to 'Biological activity of gold nanoparticles combined with the NFL-TBS.40-63 peptide, or with other cell penetrating peptides, on rat glioblastoma cells' [International Journal of Pharmaceutics: X 4 (2022) 100129]. [PDF]

Int J Pharm X
Griveau A, Arib C, Spadavecchia J, Eyer J.   +3 more
europepmc   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

Plasma membrane damage limits cytoplasmic delivery by conventional cell penetrating peptides. [PDF]

PLoS One
Polderdijk SGI, Limzerwala JF, Spiess C.
europepmc   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Cell-Penetrating Peptides and CRISPR-Cas9: A Combined Strategy for Human Genetic Disease Therapy. [PDF]

Hum Gene Ther
de Morais CCPL, Correia EM, Bonamino MH, Vasconcelos ZFM.   +3 more
europepmc   +1 more source

Tumor-Targeted Cell-Penetrating Peptides Reveal That Monomethyl Auristatin E Temporally Modulates the Tumor Immune Microenvironment. [PDF]

Molecules
Mortaja M, Cheng MM, Ali A, Lesperance J, Hingorani DV, Allevato MM, Dhawan K, Camargo MF, McKay RR, Adams SR, Gutkind JS, Advani SJ.   +11 more
europepmc   +1 more source

Cell-Penetrating Peptides Translocate across the Plasma Membrane by Inducing Vesicle Budding and Collapse. [PDF]

J Am Chem Soc
Sahni A, Ritchey JL, Qian Z, Pei D.
europepmc   +1 more source

In vitro and ex vivo screening of microRNA combinations with enhanced cell penetrating peptides to stimulate intervertebral disc regeneration. [PDF]

JOR Spine
Ní Néill T, Barcellona MN, Wilson N, O'Brien FJ, Dixon JE, Curtin CM, Buckley CT.   +6 more
europepmc   +1 more source

Discovery of a new class of cell-penetrating peptides by novel phage display platform. [PDF]

Sci Rep
Liu J, Heddleston J, Perkins DR, Chen JJH, Ghanbarpour A, Smith BW, Miles R, Aihara E, Afshar S.   +8 more
europepmc   +1 more source