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Enhancing DNA Vaccine Delivery Through Stearyl-Modified Cell-Penetrating Peptides: Improved Antigen Expression and Immune Response In Vitro and In Vivo. [PDF]
Vaccines (Basel)Jiang S, Zu C, Wang B, Zhong Y.
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, 2021 In this introductory chapter, we first define cell-penetrating peptides (CPPs), give short overview of CPP history and discuss several aspects of CPP classification. Next section is devoted to the mechanism of CPP penetration into the cells, where direct and endocytic internalization of CPP is explained.
Matjaž, Zorko, Ülo, Langel
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Prediction of Cell-Penetrating Peptides
, 2015 The in silico methods for the prediction of the cell-penetrating peptides are reviewed. Those include the multivariate statistical methods, machine-learning methods such as the artificial neural networks and support vector machines, and molecular modeling techniques including molecular docking and molecular dynamics.The applicability of the methods is ...
Mattias, Hällbrink, Mati, Karelson
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Trends in Pharmacological Sciences, 2000
The established view in cellular biology dictates that the cellular internalization of hydrophilic macromolecules can only be achieved through the classical endocytosis pathway. However, in the past five years several peptides have been demonstrated to translocate across the plasma membrane of eukaryotic cells by a seemingly energy-independent pathway.
Ülo Langel +2 more
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The established view in cellular biology dictates that the cellular internalization of hydrophilic macromolecules can only be achieved through the classical endocytosis pathway. However, in the past five years several peptides have been demonstrated to translocate across the plasma membrane of eukaryotic cells by a seemingly energy-independent pathway.
Ülo Langel +2 more
exaly +3 more sources
Classes of Cell-Penetrating Peptides
, 2015 During the three decades of cell-penetrating peptides era the superfamily of CPPs has rapidly expanded, and the quest for new sequences continues. CPPs have been well recognized by scientific community and they have been used for transduction of a wide variety of molecules and particles into cultured cells and in vivo.
Margus, Pooga, Ülo, Langel
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Predicting Cell-Penetrating Peptides
Advanced Drug Delivery Reviews, 2008Possibility to predict short peptide sequences capable to penetrate the plasma membrane opens new opportunities for developing peptide based intracellular delivery vectors, called cell-penetrating peptides (CPPs). Predictions of CPPs, however are often based on trial and error and may not always lead to new potent sequences.
Ülo Langel, Kalle Kilk, Mats Hansén
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The Pharmacokinetics of Cell-Penetrating Peptides
Molecular Pharmaceutics, 2010Cell-penetrating peptides (CPPs) are able to penetrate the cell membrane carrying cargoes such as peptides, proteins, oligonucleotides, siRNAs, radioisotopes, liposomes, and nanoparticles. Consequently, many delivery approaches have been developed to use CPPs as tools for drug delivery.
Dikran, Sarko +8 more
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Studying the uptake of cell-penetrating peptides
Nature Protocols, 2006More than a decade ago, it was discovered that cationic peptides could traverse the cellular plasma membrane without specific transporter proteins or membrane damage. Subsequently, it was found that these peptides, known as cell-penetrating peptides (CPPs), were also capable of delivering cargos into cells, hence the great potential of these vectors ...
Tina, Holm +5 more
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