Results 241 to 250 of about 5,199,365 (284)

In vitro and ex vivo screening of microRNA combinations with enhanced cell penetrating peptides to stimulate intervertebral disc regeneration. [PDF]

JOR Spine
Ní Néill T, Barcellona MN, Wilson N, O'Brien FJ, Dixon JE, Curtin CM, Buckley CT.   +6 more
europepmc   +1 more source

Discovery of a new class of cell-penetrating peptides by novel phage display platform. [PDF]

Sci Rep
Liu J, Heddleston J, Perkins DR, Chen JJH, Ghanbarpour A, Smith BW, Miles R, Aihara E, Afshar S.   +8 more
europepmc   +1 more source

Enhancing DNA Vaccine Delivery Through Stearyl-Modified Cell-Penetrating Peptides: Improved Antigen Expression and Immune Response In Vitro and In Vivo. [PDF]

Vaccines (Basel)
Jiang S, Zu C, Wang B, Zhong Y.
europepmc   +1 more source

The PSD-95 inhibitor NA-1 is delivered to the brain upon nasal administration with uptake into the olfactory bulb improved by co-administration with the cell-penetrating peptides lowPro and Tat. [PDF]

Drug Deliv Transl Res
Schmidt SE, Joensen G, Sandbjerg C, Thaysen M, Gammelgaard B, Schindowski K, Kristensen M.   +6 more
europepmc   +1 more source

Cell-Penetrating Peptides

, 2021
In this introductory chapter, we first define cell-penetrating peptides (CPPs), give short overview of CPP history and discuss several aspects of CPP classification. Next section is devoted to the mechanism of CPP penetration into the cells, where direct and endocytic internalization of CPP is explained.
Matjaž, Zorko, Ülo, Langel
openaire   +3 more sources

Prediction of Cell-Penetrating Peptides

, 2015
The in silico methods for the prediction of the cell-penetrating peptides are reviewed. Those include the multivariate statistical methods, machine-learning methods such as the artificial neural networks and support vector machines, and molecular modeling techniques including molecular docking and molecular dynamics.The applicability of the methods is ...
Mattias, Hällbrink, Mati, Karelson
openaire   +3 more sources

Classes of Cell-Penetrating Peptides

, 2015
During the three decades of cell-penetrating peptides era the superfamily of CPPs has rapidly expanded, and the quest for new sequences continues. CPPs have been well recognized by scientific community and they have been used for transduction of a wide variety of molecules and particles into cultured cells and in vivo.
Margus, Pooga, Ülo, Langel
openaire   +3 more sources

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Cell-penetrating peptides

Trends in Pharmacological Sciences, 2000
The established view in cellular biology dictates that the cellular internalization of hydrophilic macromolecules can only be achieved through the classical endocytosis pathway. However, in the past five years several peptides have been demonstrated to translocate across the plasma membrane of eukaryotic cells by a seemingly energy-independent pathway.
M, Lindgren, M, Hällbrink, A, Prochiantz, U, Langel   +3 more
openaire   +2 more sources

The Pharmacokinetics of Cell-Penetrating Peptides

Molecular Pharmaceutics, 2010
Cell-penetrating peptides (CPPs) are able to penetrate the cell membrane carrying cargoes such as peptides, proteins, oligonucleotides, siRNAs, radioisotopes, liposomes, and nanoparticles. Consequently, many delivery approaches have been developed to use CPPs as tools for drug delivery.
Dikran, Sarko, Barbro, Beijer, Regine, Garcia Boy, Eva-Maria, Nothelfer, Karin, Leotta, Michael, Eisenhut, Annette, Altmann, Uwe, Haberkorn, Walter, Mier   +8 more
openaire   +2 more sources

Predicting cell-penetrating peptides

Advanced Drug Delivery Reviews, 2008
Possibility to predict short peptide sequences capable to penetrate the plasma membrane opens new opportunities for developing peptide based intracellular delivery vectors, called cell-penetrating peptides (CPPs). Predictions of CPPs, however are often based on trial and error and may not always lead to new potent sequences.
Mats, Hansen, Kalle, Kilk, Ulo, Langel
openaire   +2 more sources