Results 51 to 60 of about 5,601,044 (283)
SCARA Involvement in the Uptake of Nanoparticles Formed by Cell-Penetrating Peptides
, 2015 The investigation of uptake mechanisms for cell-penetrating peptides (CPPs) is and has been an ongoing project for as long as the peptides have been known, a time period that now spans over two decades.
Staffan Lindberg +5 more
core +1 more source
, 2022 Enhanced Live-Cell Delivery of Synthetic Proteins Assisted by Cell-Penetrating Peptides Fused to ...
Shaswati Manda, Guy Mann, Gandhesiri Satish and Ashraf Brik
core +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Disruptin, a cell-penetrating peptide degrader of EGFR
Translational Oncology, 2021 Disruptin is a cell-permeable decoy peptide designed to destabilize activated EGFR, both by inhibiting Hsp90 chaperoning and dissociating the active asymmetric EGFR dimer, which leads to an increase in engagement of activated EGFR with the proteolytic degradation machinery and subsequent loss from the cells.
Ranjit K. Mehta +6 more
openaire +3 more sources
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
In-silico TAT-PTD prediction for cell penetrating peptides
, 2007 Cell Penetrating Peptides (CPP) enhance transport of membrane and secretory proteins across hydrophobic membranes. Natural or synthetic CPP water soluble peptides translocate across cell membranes and are used for intracellular delivery of large ...
Aggarwal, A. +4 more
core +2 more sources
Specific targeting of caspase-9/PP2A interaction as potential new anti-cancer therapy. [PDF]
PLoS ONE, 2013 PURPOSE: PP2A is a serine/threonine phosphatase critical to physiological processes, including apoptosis. Cell penetrating peptides are molecules that can translocate into cells without causing membrane damage.
Issam Arrouss +12 more
doaj +1 more source
Peptides – Molecular Allrounders
CHIMIA, 2021 The enormous structural and functional diversity available through combining different amino acids into peptides offers numerous exciting opportunities.
Helma Wennemers
doaj +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins
Frontiers in Microbiology, 2017 The increasing prevalence of multidrug-resistant bacteria urges the development of new antibacterial agents. With a broad spectrum activity, antimicrobial peptides have been considered potential antibacterial drug leads. Using bioinformatic tools we have
Susana A. Dias +11 more
doaj +1 more source