Results 31 to 40 of about 61,727 (300)

Cleavage of the vaspin N-terminus releases cell-penetrating peptides that affect early stages of adipogenesis and inhibit lipolysis in mature adipocytes

Adipocyte, 2021
Vaspin expression and function is related to metabolic disorders and comorbidities of obesity. In various cellular and animal models of obesity, diabetes and atherosclerosis vaspin has shown beneficial, protective and/or compensatory action.
Catherine A. Tindall, Estelle Erkner, Jan Stichel, Annette G. Beck-Sickinger, Anne Hoffmann, Juliane Weiner, John T. Heiker   +6 more
doaj   +1 more source

Cell-penetrating peptides [PDF]

Plant Signaling & Behavior, 2008
Internalization of cell-penetrating peptides, well described in mammalian cell system, has recently been reported in a range of plant cells by three independent groups. Despite fundamental differences between animal cell and plant cell composition, the CPP uptake pattern between the mammalian system and the plant system is very similar. Tat, Tat-2 pVEC
François, Eudes, Archana, Chugh
openaire   +2 more sources

Beyond the discovered peptides by Viktor Mutt – a contribution [PDF]

Proceedings of the Estonian Academy of Sciences
A summary of the results obtained in the collaboration between the laboratory of Prof. Viktor Mutt at Karolinska Institutet and our laboratory at Stockholm University, headed by Prof. Tamas Bartfai, is given.
Ülo Langel
doaj   +1 more source

Characterisation of cell‐penetrating peptide‐mediated peptide delivery [PDF]

British Journal of Pharmacology, 2005
Cell‐penetrating peptides such as antennapedia, TAT, transportan and polyarginine have been extensively employed for in vitro and in vivo delivery of biologically active peptides. However, little is known of the relative efficacy, toxicity and uptake mechanism of individual protein transduction domain–peptide conjugates, factors that will be critical
Jones, Simon W., Christison, Richard, Bundell, Ken, Voyce, Catherine J., Brockbank, Sarah M V, Newham, Peter, Lindsay, Mark A.   +6 more
openaire   +2 more sources

New amphiphilic amino acid derivatives for efficient DNA transfection in vitro [PDF]

, 2017
Nucleic acids-based therapies have recently developed as next-generationagents for treating and preventing viral infection, cancer, and genetic disorders,but their use is still limited due to its relatively poor delivery into targetedcells.
Antuña, Sebastián, Argarañá, María Fernanda, de Zan, María Mercedes, Giorello, Antonella, Muller, Diana, Peña, Lucía Carolina, Prieto, Claudio, Veaute, Carolina Melania Isabel   +7 more
core   +1 more source

Ligands for oral delivery of peptides across the blood-brain-barrier

Acta Materia Medica, 2022
Peptides are short chains of amino acids linked by peptide bonds. Many peptides and proteins are limited by their poor enzymatic stability and permeability across the intestinal epithelial membranes and/or blood-brain barrier (BBB).
Murad Al Gailani, Mengyang Liu, Jingyuan Wen   +2 more
doaj   +1 more source

Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide. [PDF]

, 2016
Malignant gliomas have poor prognosis and urgently require new therapies. Activating Transcription Factor 5 (ATF5) is highly expressed in gliomas, and interference with its expression/function precipitates targeted glioma cell apoptosis in vitro and in ...
Angelastro, James, Arias, Angelo, Cates, Charles, Cayanan, Geraldine, Fung, Jennifer, Greene, Lloyd, Karpel-Massler, Georg, Lamé, Michael, Nakayama Wong, Lynn, Rowland, Douglas, Sidorov, Maxim, Siegelin, Markus   +11 more
core   +2 more sources

Novel approaches in development of cell penetrating peptides

Journal of Applied Pharmaceutical Research, 2021
Therapeutic cargos which are impermeable to the cell can be delivered by cell penetrating peptides (CPPs). CPP-cargo complexes accumulate by endocytosis inside the cells but they fail to reach the cytosolic space properly as they are often trapped in the
Vatsal R. Shah, Yamini D. Shah, Mansi N. Athalye   +2 more
doaj   +1 more source

Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]

, 2013
Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P., Cooper, A., Curreli, F., Debnath, A.K., Freed, E.O., Lee, S., Mehta, M., Mercredi, P.Y., Scacalossi, D., Summers, M.F., Tong, X., Waheed, A.A., Zhang, H.   +12 more
core   +2 more sources

Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin [PDF]

, 2002
Besides its physiological role in lysosomal protein breakdown, extralysosomal cathepsin B has recently been implicated in apoptotic cell death. Highly specific irreversible cathepsin B inhibitors that are readily cellpermeant should be useful tools to ...
Assfalg-Machleidt, Irmgard, Deluca, Dominga, Höhneke, Clara, Machleidt, Werner, Schaschke, Norbert, Sommerhoff, Christian P.   +5 more
core   +1 more source