Results 21 to 30 of about 5,601,044 (283)

Potent antitumor effects of cell-penetrating peptides targeting STAT3 axis

JCI Insight, 2021
To date, there are no inhibitors that directly and specifically target activated STAT3 and c-Myc in the clinic. Although peptide-based inhibitors can selectively block activated targets, their clinical usage is limited because of low cell penetration and/
Maryam Aftabizadeh, Yi-Jia Li, Qianqian Zhao, Chunyan Zhang, Nigus Ambaye, Jieun Song, Toshikage Nagao, Christoph Lahtz, Marwan Fakih, David K. Ann, Hua Yu, Andreas Herrmann   +11 more
doaj   +1 more source

Cleavage of the vaspin N-terminus releases cell-penetrating peptides that affect early stages of adipogenesis and inhibit lipolysis in mature adipocytes

Adipocyte, 2021
Vaspin expression and function is related to metabolic disorders and comorbidities of obesity. In various cellular and animal models of obesity, diabetes and atherosclerosis vaspin has shown beneficial, protective and/or compensatory action.
Catherine A. Tindall, Estelle Erkner, Jan Stichel, Annette G. Beck-Sickinger, Anne Hoffmann, Juliane Weiner, John T. Heiker   +6 more
doaj   +1 more source

Arginine‐rich cell‐penetrating peptides [PDF]

FEBS Letters, 2009
Arginine‐rich cell‐penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells. While successful intracellular delivery of many biologically active macromolecules has been accomplished using these peptides, their mechanisms of cell entry are still under investigation. Recent dialogue has centered on a
Schmidt, Nathan, Mishra, Abhijit, Lai, Ghee Hwee, Wong, Gerard C.L.   +3 more
openaire   +2 more sources

Hybrid peptides inspired by the RWQWRWQWR sequence inhibit cervical cancer cells growth in vitro [PDF]

Exploration of Drug Science
Aim: The aim of this research was to generate new peptide molecules with cytotoxic activity against cervical cancer that can become effective in mitigating the impact of the disease and preventing its progression.
Natalia Ardila-Chantré, Claudia Marcela Parra-Giraldo, Yerly Vargas-Casanova, Andrea Carolina Barragán-Cardenas, Ricardo Fierro-Medina, Zuly Jenny Rivera-Monroy, Jhon Erick Rivera-Monroy, Javier Eduardo García-Castañeda   +7 more
doaj   +1 more source

A manganese (II)-based coordinative dendrimer with robust efficiency in intracellular peptide delivery

Bioactive Materials, 2022
Peptides have gained increasing interests as drug candidates in modern pharmaceutical industry, however, the development of peptide drugs acting on intracellular targets is limited due to their membrane impermeability.
Lanfang Ren, Yang Gao, Yiyun Cheng
doaj   +1 more source

Uptake of cell‐penetrating peptides in yeasts [PDF]

FEBS Letters, 2005
The uptake of different cell‐penetrating peptides (CPPs) in two yeast species, Saccharomyces cerevisiae and Candida albicans, was studied using fluorescence HPLC‐analyses of cell content. Comparison of the ability of penetratin, pVEC and (KFF)3K to traverse the yeast cell envelope shows that the cellular uptake of the peptides varies widely.
Holm, Tina, Netzereab, Semharai, Hansen, Mats, Langel, Ülo, Hällbrink, Mattias   +4 more
openaire   +2 more sources

Mitochondrial Targeting Probes, Drug Conjugates, and Gene Therapeutics

, 2021
Mitochondria represent an important drug target for many phatology, including neurodegeneration, metabolic disease, heart failure, ischemia-reperfusion injury, and cancer.
Tove Kivijärvi, Cerrato, Carmine Pasquale, Cerrato, C. P.,, Kivijärvi, T, Carmine Pasquale Cerrato, Ülo Langel, Kivijärvi, Tove, Langel, Ülo,, Langel, Ü, Cerrato, CP, Kivijärvi, Tove,, Langel, Ü.,   +11 more
core   +1 more source

Beyond the discovered peptides by Viktor Mutt – a contribution [PDF]

Proceedings of the Estonian Academy of Sciences
A summary of the results obtained in the collaboration between the laboratory of Prof. Viktor Mutt at Karolinska Institutet and our laboratory at Stockholm University, headed by Prof. Tamas Bartfai, is given.
Ülo Langel
doaj   +1 more source

Ligands for oral delivery of peptides across the blood-brain-barrier

Acta Materia Medica, 2022
Peptides are short chains of amino acids linked by peptide bonds. Many peptides and proteins are limited by their poor enzymatic stability and permeability across the intestinal epithelial membranes and/or blood-brain barrier (BBB).
Murad Al Gailani, Mengyang Liu, Jingyuan Wen   +2 more
doaj   +1 more source

Internalization mechanisms of cell-penetrating peptides

Beilstein Journal of Nanotechnology, 2020
In today’s modern era of medicine, macromolecular compounds such as proteins, peptides and nucleic acids are dethroning small molecules as leading therapeutics. Given their immense potential, they are highly sought after.
Ivana Ruseska, Andreas Zimmer
doaj   +1 more source