Results 151 to 160 of about 26,893,016 (421)

Cell Migration: Integrating Signals from Front to Back

Science, 2003
Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis.
A. Ridley, M. Schwartz, K. Burridge, R. Firtel, M. Ginsberg, G. Borisy, J. Parsons, A. R. Horwitz   +7 more
semanticscholar   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB [PDF]

, 2016
Adult neural stem cells (NSCs) are defined by their inherent capacity to self-renew and give rise to neurons, astrocytes, and oligodendrocytes. In vivo, however, hippocampal NSCs do not generate oligodendrocytes for reasons that have remained enigmatic ...
Alice Grison, Andrea Erni, Anna Engler, Barry, Bonaguidi, Braun, Chang, Chiara Rolando, Chong, Davis, Deneen, Encinas, Gronostajski, Ha, Hack, Han, Harris, Hüttmann, Ihrie, Jessberger, Johanson, Kang, Karginov, Knuckles, Kriegstein, Kronenberg, Lee, Lugert, Lugert, Macias, Macias, Marta Milo, Menn, Merkle, Messina, Ninkovic, Paul J. Gokhale, Pedersen, Petrus, Piper, Robert Beattie, Santarelli, Sebastian Jessberger, Seong, Sierra, Song, Steele-Perkins, Steiner, Suh, Sun, Thomas Wegleiter, Verdon Taylor   +51 more
core   +2 more sources

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line

Journal of Cell Biology, 1988
In contrast to mouse epidermal cells, human skin keratinocytes are rather resistant to transformation in vitro. Immortalization has been achieved by SV40 but has resulted in cell lines with altered differentiation.
P. Boukamp, Rule T Petrussevska, D. Breitkreutz, Jiirgen Hornung, Alex Markham, N. Fusenig   +5 more
semanticscholar   +1 more source

Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function [PDF]

, 2012
Background/Aims: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic β-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion.
Bennett, J., Hills, C. E., Liu, K.-K., Siamantouras, E., Squires, P. E., Younis, M. Y.G.   +5 more
core   +2 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Ezh2 Expression in Astrocytes Induces Their Dedifferentiation Toward Neural Stem Cells [PDF]

, 2011
Recently, we have demonstrated the expression of the polycomb group protein Ezh2 in embryonic and adult neural stem cells. Although Ezh2 remained highly expressed when neural stem cells differentiate into oligodendrocyte precursor cells, it is ...
Boddeke, Erik, Copray, Sjef, Sher, Falak
core   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Observations of cellular responses to diamagnetic forces acting on cell components

Science and Technology of Advanced Materials, 2008
The magnetooptical measurements of the properties of living cells have a potentially large impact on cellular engineering and biotechnology because the noninvasive approach to applying magnetic fields on cells enables the detection of the dynamics of ...
Masakazu Iwasaka et al
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