Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment
Frontiers in Immunology, 2019 The immune system and cancer have a complex relationship with the immune system playing a dual role in tumor development. The effector cells of the immune system can recognize and kill malignant cells while immune system-mediated inflammation can also ...
Heidi Harjunpää +3 more
semanticscholar +1 more source
Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes [PDF]
, 2016 Desmosomes are adhesion plaques that mediate cell-cell adhesion in many tissues, including the epidermis, and generate mechanical resistance to tissues. The extracellular domains of desmosomal cadherin proteins, desmogleins and desmocollins, are required
Ali, Jawahir +7 more
core +1 more source
Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer
International Journal of Molecular Sciences, 2018 Tumor necrosis factor alpha (TNFα) is a pro-inflammatory cytokine that triggers the expression of inflammatory molecules, including other cytokines and cell adhesion molecules.
Deok-Hoon Kong +4 more
semanticscholar +1 more source
A Method to Culture GABAergic Interneurons Derived from the Medial Ganglionic Eminence
Frontiers in Cellular Neuroscience, 2018 Understanding the mechanisms guiding interneuron development is a central aspect of the current research on cortical/hippocampal interneurons, which is highly relevant to brain function and pathology.
Sira A. Franchi +8 more
doaj +1 more source
Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfment
iScience, 2022 Summary: Entosis is a cell competition process during which tumor cells engulf other tumor cells. It is initiated by metabolic stress or by loss of matrix adhesion, and it provides the winning cell with resources derived from the internalized cell. Using
Mariel F. Schwietzer +8 more
doaj +1 more source
Journal of Cellular Physiology, 2007 AbstractThe complex interactions of cells with extracellular matrix (ECM) play crucial roles in mediating and regulating many processes, including cell adhesion, migration, and signaling during morphogenesis, tissue homeostasis, wound healing, and tumorigenesis. Many of these interactions involve transmembrane integrin receptors.
Allison L. Berrier, Kenneth M. Yamada
openaire +3 more sources
FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions
Biomolecules, 2020 Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the regulation of cell adhesion migration, proliferation and survival. In cancer FAK is a major driver of invasion and metastasis and its upregulation is associated with poor
Paula Tapial Martínez +2 more
doaj +1 more source
Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis
Frontiers in Immunology, 2019 Cell-cell interactions and cell adhesion are key mediators of cancer progression and facilitate hallmarks of cancer including immune evasion and metastatic dissemination.
H. Läubli, L. Borsig
semanticscholar +1 more source
Differential Roles of Dendritic Cells in Expanding CD4 T Cells in Sepsis
Biomedicines, 2019 Sepsis is a systemically dysregulated inflammatory syndrome, in which dendritic cells (DCs) play a critical role in coordinating aberrant immunity. The aim of this study is to shed light on the differential roles played by systemic versus mucosal DCs in ...
Samuel Darkwah +6 more
doaj +1 more source
Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis
Frontiers in Oncology, 2018 Metastasis is a multistep process in which tumor extracellular matrix (ECM) and cancer cell cytoskeleton interactions are pivotal. ECM is connected, through integrins, to the cell’s adhesome at cell–ECM adhesion sites and through them to the actin ...
V. Gkretsi, T. Stylianopoulos
semanticscholar +1 more source