Results 41 to 50 of about 805,424 (161)
Nature CommunicationsTalin regulates crucial cellular functions, including cell adhesion and motility, and affects human diseases. Triggered by mechanical forces, talin plays crucial roles in facilitating the formation of focal adhesions and recruiting essential focal ...
Erumbi S. Rangarajan +3 more
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Scientific Reports, 2017 Mutations in the X-linked gene Protocadherin-19 (Pcdh19) cause female-limited epilepsy and mental retardation in humans. Although Pcdh19 is known to be a homophilic cell-cell adhesion molecule, how its mutations bring about female-specific disorders ...
Shuichi Hayashi +6 more
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The Rac3 GTPase in Neuronal Development, Neurodevelopmental Disorders, and Cancer
Cells, 2019 Rho family small guanosine triphosphatases (GTPases) are important regulators of the cytoskeleton, and are critical in many aspects of cellular and developmental biology, as well as in pathological processes such as intellectual disability and cancer. Of
Ivan de Curtis
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Human Microphysiological Models of Intestinal Tissue and Gut Microbiome
Frontiers in Bioengineering and Biotechnology, 2020 The gastrointestinal (GI) tract is a complex system responsible for nutrient absorption, digestion, secretion, and elimination of waste products that also hosts immune surveillance, the intestinal microbiome, and interfaces with the nervous system ...
Steven N. Steinway +5 more
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Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis
Critical Care Research and Practice, 2012 Deregulated interplay between inflammation and coagulation plays a pivotal role in the pathogenesis of sepsis. Therapeutic approaches that simultaneously target both inflammation and coagulation hold great promise for the treatment of sepsis ...
Takayuki Okamoto +3 more
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Liquid–liquid phase separation in neural development
Cellular and Molecular Life SciencesLiquid–liquid phase separation (LLPS) is a physicochemical process in which a homogeneous mixture of molecules separates into a denser phase originating from preferential self-assembly, driven by multivalent interactions, frequently mediated by ...
Sara Surini, Ivan de Curtis
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Dual specificity kinase DYRK3 regulates cell migration by influencing the stability of protrusions
iScienceSummary: Plasma membrane-associated platforms (PMAPs) form at specific sites of plasma membrane by scaffolds including ERC1 and Liprin-α1. We identify a mechanism regulating PMAPs assembly, with consequences on motility/invasion. Silencing Ser/Thr kinase
Martina Ramella +8 more
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Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity
Nature Communications, 2017 EpCAM is an unconventional epithelia-specific cell–cell adhesion molecule, that is mutated in the majority of cases of Congenital Tufting Enteropathy. Here the authors show that loss of EpCAM causes a concentration of contractile activity at tricellular ...
Julie Salomon +17 more
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Update on the Clot Waveform Analysis
Clinical and Applied Thrombosis/Hemostasis, 2020 The activated partial thromboplastin time (APTT)–clot waveform analysis (CWA) was previously reported to be associated with the early detection of disseminated intravascular coagulation and was also reported to be able to measure very low levels of ...
Hideo Wada MD, PhD +4 more
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Journal of Cachexia, Sarcopenia and MuscleBackground Intensive care unit‐acquired weakness (ICU‐AW) is a syndrome characterized by a long‐term muscle weakness often observed in sepsis‐surviving patients during the chronic phase.
Yuichi Akama +12 more
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