Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis
Frontiers in Immunology, 2019 Cell-cell interactions and cell adhesion are key mediators of cancer progression and facilitate hallmarks of cancer including immune evasion and metastatic dissemination.
H. Läubli, L. Borsig
semanticscholar +1 more source
Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1
Communications Biology, 2023 Scribble (Scrib) is a multidomain polarity protein and member of the leucine-rich repeat and PDZ domain (LAP) protein family. A loss of Scrib expression is associated with disturbed apical-basal polarity and tumor formation.
Eva-Maria Thüring +9 more
doaj +1 more source
MicroRNA Profiles in Intestinal Epithelial Cells in a Mouse Model of Sepsis
Cells, 2023 Sepsis is a systemic inflammatory disorder that leads to the dysfunction of multiple organs. In the intestine, the deregulation of the epithelial barrier contributes to the development of sepsis by triggering continuous exposure to harmful factors ...
Siqingaowa Caidengbate +9 more
doaj +1 more source
Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis
Frontiers in Oncology, 2018 Metastasis is a multistep process in which tumor extracellular matrix (ECM) and cancer cell cytoskeleton interactions are pivotal. ECM is connected, through integrins, to the cell’s adhesome at cell–ECM adhesion sites and through them to the actin ...
V. Gkretsi, T. Stylianopoulos
semanticscholar +1 more source
GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity. [PDF]
, 2016 Abnormal activation of the epidermal growth factor receptor (EGFR) due to a deletion of exons 2-7 of EGFR (EGFRvIII) is a common alteration in glioblastoma (GBM). While this alteration can drive gliomagenesis, tumors harboring EGFRvIII are heterogeneous.
David James, C +11 more
core +1 more source
Cell adhesion is regulated by CDK1 during the cell cycle
Journal of Cell Biology, 2018 In most tissues, anchorage-dependent growth and cell cycle progression are dependent on cells engaging extracellular matrices (ECMs) via integrin–receptor adhesion complexes.
Matthew C. Jones +3 more
semanticscholar +1 more source
Hydroxyapatite promotes superior adhesion and proliferation of telomerase transformed keratocytes in comparison with inert plastic skirt materials used in leading contemporary keratoprostheses [PDF]
, 2005 Aim: Published clinical series suggest the osteoodontokeratoprosthesis (OOKP) may have a lower extrusion rate than current synthetic keratoprostheses. The OOKP is anchored in the eye wall by autologous tooth.
Allen, B.D.S. +6 more
core +2 more sources
Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function [PDF]
, 2012 Background/Aims: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic β-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion.
Bennett, J. +5 more
core +2 more sources
Structural basis for interdomain communication in SHIP2 providing high phosphatase activity
eLife, 2017 SH2-containing-inositol-5-phosphatases (SHIPs) dephosphorylate the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) and play important roles in regulating the PI3K/Akt pathway in physiology and disease.
Johanne Le Coq +7 more
doaj +1 more source
The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules [PDF]
, 2016 Multicellular organisms rely on cell adhesion molecules to coordinate cell–cell interactions, and to provide navigational cues during tissue formation.
Davies, Shireen-Anne +7 more
core +2 more sources