Results 61 to 70 of about 1,284,667 (374)

Conformational flexibility determines the Nf2/merlin tumor suppressor functions

Matrix Biology Plus, 2021
The Neurofibromatosis type 2 gene encodes the Nf2/merlin tumor suppressor protein that is responsible for the regulation of cell proliferation. Once activated, Nf2/merlin modulates adhesive signaling pathways and thereby inhibits cell growth.
Marina C. Primi, Erumbi S. Rangarajan, Dipak N. Patil, Tina Izard   +3 more
doaj  

How ICU Patient Severity Affects Communicative Interactions Between Healthcare Professionals: A Study Utilizing Wearable Sociometric Badges

Frontiers in Medicine, 2020
Numerous factors affecting the interactions between healthcare professionals in the workplace demand a comprehensive understanding if the quality of patient healthcare is to be improved.
Eiji Kawamoto, Eiji Kawamoto, Asami Ito-Masui, Asami Ito-Masui, Ryo Esumi, Ryo Esumi, Hiroshi Imai, Motomu Shimaoka   +7 more
doaj   +1 more source

Computational model combined with in vitro experiments to analyse mechanotransduction during mesenchymal stem cell adhesion [PDF]

European Cells and Materials, 2013, 25, pp.97-113, 2019
The shape that stem cells reach at the end of adhesion process influences their differentiation. Rearrangement of cytoskeleton and modification of intracellular tension may activate mechanotransduction pathways controlling cell commitment. In the present study, the mechanical signals involved in cell adhesion were computed in in vitro stem cells of ...
arxiv   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Hydroxyapatite promotes superior adhesion and proliferation of telomerase transformed keratocytes in comparison with inert plastic skirt materials used in leading contemporary keratoprostheses [PDF]

, 2005
Aim: Published clinical series suggest the osteoodontokeratoprosthesis (OOKP) may have a lower extrusion rate than current synthetic keratoprostheses. The OOKP is anchored in the eye wall by autologous tooth.
Allen, B.D.S., Faragher, R.G.A.F., Futter, C., Hing, K.A., Mehta, J., Sandeman, S.R., Tanner, K.E.   +6 more
core   +2 more sources

Junctional ER Organization Affects Mechanotransduction at Cadherin-Mediated Adhesions

Frontiers in Cell and Developmental Biology, 2021
Cadherin-mediated adhesions (also known as adherens junctions) are adhesive complexes that connect neighboring cells in a tissue. While the role of the actin cytoskeleton in withstanding tension at these sites of contact is well documented, little is ...
Michelle Joy-Immediato, Manuel J. Ramirez, Mauricio Cerda, Mauricio Cerda, Yusuke Toyama, Yusuke Toyama, Andrea Ravasio, Pakorn Kanchanawong, Pakorn Kanchanawong, Cristina Bertocchi   +9 more
doaj   +1 more source

Synthesis and Cell Adhesive Properties of Linear and Cyclic RGD Functionalized Polynorbornene Thin Films [PDF]

, 2012
Described herein is the efficient synthesis and evaluation of bioactive arginine-glycine-aspartic acid (RGD) functionalized polynorbornene-based materials for cell adhesion and spreading.
Fong, Eileen, Grubbs, Robert H., Ho, Wilson C., Kiser, Rosemary Conrad, Lu, Ying Y., Patel, Paresma R., Tirrell, David A.   +6 more
core   +2 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Irisin promotes intestinal epithelial cell proliferation via Wnt/β-catenin and focal adhesion kinase signaling pathways

Scientific Reports
The regeneration of epithelia is crucial for maintaining intestinal homeostasis. Irisin is an exercise-induced hormone originally found to be secreted by skeletal muscles, thereby regulating energy metabolism.
Arong Gaowa, Supasuta Leangpanich, Eun Jeong Park, Eiji Kawamoto, Motomu Shimaoka   +4 more
doaj   +1 more source

Nonlocal adhesion models for two cancer cell phenotypes in a multidimensional bounded domain [PDF]

, 2020
Cell-cell adhesion is an inherently nonlocal phenomenon. Numerous partial differential equation models with nonlocal term have been recently presented to describe this phenomenon, yet the mathematical properties of nonlocal adhesion model are not well understood. Here we consider a model with two kinds of nonlocal cell-cell adhesion, satisfying no-flux
arxiv   +1 more source