Results 61 to 70 of about 11,393,861 (364)

High-resolution snapshots of the talin auto-inhibitory states suggest roles in cell adhesion and signaling

Nature Communications
Talin regulates crucial cellular functions, including cell adhesion and motility, and affects human diseases. Triggered by mechanical forces, talin plays crucial roles in facilitating the formation of focal adhesions and recruiting essential focal ...
Erumbi S. Rangarajan, Julian L. Bois, Scott B. Hansen, Tina Izard   +3 more
doaj   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

YAP regulates cell mechanics by controlling focal adhesion assembly

Nature Communications, 2017
Hippo effectors YAP/TAZ act as on–off mechanosensing switches by sensing modifications in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has been described by a hierarchical model in which elements of Hippo pathway
G. Nardone, Jorge Oliver-De La Cruz, Jan Vrbsky, Cecilia Martini, J. Přibyl, P. Skládal, M. Pešl, G. Caluori, S. Pagliari, Fabiana Martino, Zuzana Macečková, M. Hajdůch, Andres Sanz-Garcia, Nicola Maria Pugno, G. Stokin, G. Forte   +15 more
semanticscholar   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfment

iScience, 2022
Summary: Entosis is a cell competition process during which tumor cells engulf other tumor cells. It is initiated by metabolic stress or by loss of matrix adhesion, and it provides the winning cell with resources derived from the internalized cell. Using
Mariel F. Schwietzer, Sonja Thölmann, Daniel Kummer, Anne Kaschler, Lilo Greune, Eva-Maria Thüring, M. Alexander Schmidt, Volker Gerke, Klaus Ebnet   +8 more
doaj  

Human Microphysiological Models of Intestinal Tissue and Gut Microbiome

Frontiers in Bioengineering and Biotechnology, 2020
The gastrointestinal (GI) tract is a complex system responsible for nutrient absorption, digestion, secretion, and elimination of waste products that also hosts immune surveillance, the intestinal microbiome, and interfaces with the nervous system ...
Steven N. Steinway, Jad Saleh, Bon-Kyoung Koo, Delphine Delacour, Deok-Ho Kim, Deok-Ho Kim   +5 more
doaj   +1 more source

Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells

Cell Adhesion & Migration, 2021
A cytoskeletal protein keratin 19 (K19) is highly expressed in breast cancer but its effects on breast cancer cell mechanics are unclear. In MCF7 cells where K19 expression is ablated, we found that K19 is required to maintain rounded epithelial-like ...
Sarah Alsharif, Pooja Sharma, Karina Bursch, Rachel Milliken, Van Lam, Arwa Fallatah, Thuc Phan, Meagan Collins, Priya Dohlman, Sarah Tiufekchiev, Georges Nehmetallah, Christopher B. Raub, Byung Min Chung   +12 more
doaj   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

A role for GLUT3 in glioblastoma cell invasion that is not recapitulated by GLUT1

Cell Adhesion & Migration, 2021
The multifaceted roles of metabolism in invasion have been investigated across many cancers. The brain tumor glioblastoma (GBM) is a highly invasive and metabolically plastic tumor with an inevitable recurrence. The neuronal glucose transporter 3 (GLUT3)
Catherine J Libby, Sajina Gc, Gloria A. Benavides, Jennifer L. Fisher, Sarah E. Williford, Sixue Zhang, Anh Nhat Tran, Emily R. Gordon, Amber B. Jones, Kaysaw Tuy, William Flavahan, Juan Gordillo, Ashlee Long, Sara J. Cooper, Brittany N. Lasseigne, Corinne E. Augelli-Szafran, Victor Darley-Usmar, Anita B. Hjelmeland   +17 more
doaj   +1 more source