Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis [PDF]
, 2013 April Hargreaves +7 more
openalex +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Correction to: The Involvement of Cell Adhesion Molecules, Tight Junctions, and Gap Junctions in Human Placentation [PDF]
, 2020 Enoch Appiah Adu‐Gyamfi +7 more
openalex +1 more source
AB0568 CLINICAL USE OF ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE, HEMOPEXIN, AND PEROXIREDOXIN 6: A POTENTIAL URINE BIOMARKER FOR KOREAN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS [PDF]
, 2023 J. W. Kim +3 more
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis
International Journal of Cell Biology, 2012 Metastasis is a major clinical problem and results in a poor prognosis for most cancers. The metastatic pathway describes the process by which cancer cells give rise to a metastatic lesion in a new tissue or organ.
Chee Wai Wong +2 more
doaj +1 more source
Leukemic thyroiditis as the initial relapsing sign in a patient with acute lymphocytic leukemia and blast expression of the neural cell adhesion molecule [PDF]
, 1997 John C. Byrd +6 more
openalex +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
S fimbriae of uropathogenic Escherichia coli bind to primary human renal proximal tubular epithelial cells but do not induce expression of intercellular adhesion molecule 1 [PDF]
, 1995 Burkhard Kreft +8 more
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