Results 211 to 220 of about 5,639,145 (346)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Joint line obliquity change was associated with femoral and tibial resection patterns and smaller final flexion imbalance after robot-assisted total knee arthroplasty. [PDF]

J Exp Orthop
Morita Y, Shin J, El-Hassan M, Shichman I, Long WJ, Sculco PK.   +5 more
europepmc   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

A Rare Case of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) in a Transgender Patient With Exclusive Smooth Implant Exposure. [PDF]

Cureus
English R, Aguilar R, Kan Hwee Y, Greenfield S, Marshall D, Oblena K, Schwartz G.   +6 more
europepmc   +1 more source

Impact of ultraviolet radiation on skin cell redox balance and phenolic-based photoprotection strategies

Ewelina Gołębiewska, Monika Kalinowska, Marcin Zieliński, Marek Pruszyński   +3 more
openalex   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Protein-protein interaction network architecture of human polygenic traits reveals domain-spanning connectivity and evolutionary pressures. [PDF]

Genome Biol
Tamandeh E, Kunwar K, Bigge J, Serohijos A, Schumacher J, Maj C, Dasmeh P.   +6 more
europepmc   +1 more source

Comparative Analysis of Passive and Active Cell Balancing Techniques for Electric Vehicle Battery Packs

Sefa Mert Köylü, Harun ÖZBAY
openalex   +2 more sources

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source