Results 131 to 140 of about 8,046,202 (313)

Cdc42p and Fus2p act together late in yeast cell fusion

, 2012
Cell fusion is the key event of fertilization that gives rise to the diploid zygote and is a nearly universal aspect of eukaryotic biology. In the yeast Saccharomyces cerevisiae, several mutants have been identified that are defective for cell fusion ...
Stein, Richard A, Ydenberg, Casey A, Rose, Mark D   +2 more
core   +1 more source

RNAi screen reveals a role for PACSIN2 and caveolins during bacterial cell-to-cell spread

, 2020
Listeria monocytogenes is a human bacterial pathogen that disseminates through host tissues using a process called cell-to-cell spread. This critical yet understudied virulence strategy resembles a vesicular form of intercellular trafficking that allows ...
Sanderlin, Allen G, Ahyong, Vida, Vondrak, Cassandra, Fedrigo, Indro, Scricco, Arianna J., Lamason, Rebecca L.   +5 more
core   +1 more source

Dynamic remodeling of septin structures fine-tunes myogenic differentiation

iScience
Summary: Controlled myogenic differentiation is integral to the development, maintenance and repair of skeletal muscle, necessitating precise regulation of myogenic progenitors and resident stem cells.
Vladimir Ugorets, Paul-Lennard Mendez, Dmitrii Zagrebin, Giulia Russo, Yannic Kerkhoff, Georgios Kotsaris, Jerome Jatzlau, Sigmar Stricker, Petra Knaus   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Expressional assessment of mouse embryonic stem cell, lung cancer and somatic fibroblast cell lines on the basis of EMT, MAPK and Inflammation.

, 2017
Annual Joint Meeting of the American-Society-for-Cell-Biology and the European-Molecular-Biology-Organization (ASCB/EMBO) -- DEC 02-06, 2017 -- Philadelphia, PAAmer Soc Cell Biol, European Mol Biol ...
Gurel, C., Aktug, H., Kocaturk, D. Calik, Acikgoz, E., Oktem, G., Mukhtarova, G. Gursel, Oltulu, F., Uysal, A., Ozdil, B., Adali, Y., Yavasoglu, A.   +10 more
core  

Extracellular matrix composition and stiffness regulates progesterone responsiveness and decidualization

iScience
Summary: Endometrial disorders impact the uterine lining and can promote ectopic endometrial tissue growth. A key feature of endometrial disorders is unresponsiveness to hormonal treatments due to progesterone resistance.
Danielle Klunk, Laura Homewood, Daniel Abebayehu   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Compairment of autophagy and mTOR pathways in mouse embryonic stem cell, lung cancer and somatic fibroblast cell lines in molecular analysis base.

, 2017
Annual Joint Meeting of the American-Society-for-Cell-Biology and the European-Molecular-Biology-Organization (ASCB/EMBO) -- DEC 02-06, 2017 -- Philadelphia, PAAmer Soc Cell Biol, European Mol Biol ...
Gurel, C., Aktug, H., Kocaturk, D. Calik, Acikgoz, E., Oktem, G., Oltulu, F., Uysal, A., Ozdil, B., Adali, Y., Yavasoglu, A.   +9 more
core  

Protocol for the dissociation of adult human primary cardiomyocytes using a methylcellulose-supplemented digestion solution

STAR Protocols
Summary: Human primary cardiomyocytes are a valuable in vitro model for studying human heart physiology and disease. Here, we present a protocol for the dissociation of adult human primary cardiomyocytes using a methylcellulose-supplemented digestion ...
Xun Shi, Yafei Huang, Bingying Zhou
doaj   +1 more source