Results 51 to 60 of about 14,886,212 (348)

Universal Cell Embeddings: A Foundation Model for Cell Biology

bioRxiv
Developing a universal representation of cells which encompasses the tremendous molecular diversity of cell types within the human body and more generally, across species, would be transformative for cell biology.
Yanay Rosen, Yusuf H. Roohani, Ayush Agrawal, Leon Samotorčan, S. Quake, J. Leskovec   +5 more
semanticscholar   +1 more source

Cell biology, SevERing mitochondria

, 2011
The endoplasmic reticulum is an active participant in the division of another organelle, the ...
Lippincott-Schwarz, J., Rambold, A.
core   +1 more source

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

Nature Communications, 2020
Glucagon is elevated Type-2 diabetes, which contributes to poor glucose control in patients with the disease. Here the authors report that secretion of the hormone is controlled by paracrine inhibition, and that resistance of α-cells to somatostatin can ...
Muhmmad Omar-Hmeadi, Per-Eric Lund, Nikhil R. Gandasi, Anders Tengholm, Sebastian Barg   +4 more
doaj   +1 more source

Identification of embryonic RNA granules that act as sites of mRNA translation after changing their physical properties

iScience, 2022
Summary: Fertilized eggs begin to translate mRNAs at appropriate times and placements to control development, but how the translation is regulated remains unclear.
Keisuke Sato, Moeko Sakai, Anna Ishii, Kaori Maehata, Yuki Takada, Kyota Yasuda, Tomoya Kotani   +6 more
doaj   +1 more source

The implications of FASN in immune cell biology and related diseases

Cell Death and Disease
Fatty acid metabolism, particularly fatty acid synthesis, is a very important cellular physiological process in which nutrients are used for energy storage and biofilm synthesis. As a key enzyme in the fatty acid metabolism, fatty acid synthase (FASN) is
Yucai Xiao, Yonghong Yang, Huabao Xiong, Guanjun Dong   +3 more
semanticscholar   +1 more source

Ferroptosis in Cancer Cell Biology

Cancers, 2020
A major hallmark of cancer is successful evasion of regulated forms of cell death. Ferroptosis is a recently discovered type of regulated necrosis which, unlike apoptosis or necroptosis, is independent of caspase activity and receptor-interacting protein
Christina M. Bebber, F. Müller, Laura Prieto Clemente, Joseph C. Weber, S. von Karstedt   +4 more
semanticscholar   +1 more source

SBML models and MathSBML [PDF]

, 2008
MathSBML is an open-source, freely-downloadable Mathematica package that facilitates working with Systems Biology Markup Language (SBML) models. SBML is a toolneutral,computer-readable format for representing models of biochemical reaction networks ...
Shapiro, B.E., Finney, A., Hucka, M., Bornstein, B., Funahashi, A., Jouraku, A., Keating, S., Le Novere, N., Matthews, J., Schilstra, M.   +9 more
core   +2 more sources

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source

Acetyl-NPKY of integrin-β1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity

iScience
Summary: Integrin-dependent crosstalk between cell-matrix adhesions and cell-cell junctions is critical for controlling endothelial permeability and proliferation in cancer and inflammatory diseases but remains poorly understood.
Adama Sidibé, Vasyl V. Mykuliak, Pingfeng Zhang, Vesa P. Hytönen, Jinhua Wu, Bernhard Wehrle-Haller   +5 more
doaj   +1 more source

How chromosomal translocations arise to cause cancer: Gene proximity, trans-splicing, and DNA end joining

iScience, 2023
Summary: Chromosomal translocations (CTs) are a genetic hallmark of cancer. They could be identified as recurrent genetic aberrations in hemato-malignancies and solid tumors. More than 40% of all “cancer genes” were identified in recurrent CTs.
Patrick Streb, Eric Kowarz, Tamara Benz, Jennifer Reis, Rolf Marschalek   +4 more
doaj   +1 more source