Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
Glucagon is elevated Type-2 diabetes, which contributes to poor glucose control in patients with the disease. Here the authors report that secretion of the hormone is controlled by paracrine inhibition, and that resistance of α-cells to somatostatin can ...
Muhmmad Omar-Hmeadi +4 more
doaj +1 more source
Reproducibility and cell biology [PDF]
![Figure][1] © Sidney Harris The New Yorker Collection/The Cartoon Bank Growing concerns about the reproducibility of published research threaten to undermine the scientific enterprise and erode public trust.
Yamada, Kenneth M., Hall, Alan
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Oxidant radicals release by alveolar macrophages after CdCl2 exposure in vitro: Symposium of Cell Biology [PDF]
Organized by the Belgian Society of Pneumology and the Scientific Assembly of Cell Biology of the European Respiratory Societyinfo:eu-repo/semantics ...
Wallaert, Benoît +4 more
core
Cellular logistics: Unraveling the interplay between microtubule organization and intracellular transport [PDF]
Microtubules are core components of the cytoskeleton and serve as tracks for motor protein-based intracellular transport. Microtubule networks are highly diverse across different cell types and are believed to adapt to cell type-specific transport ...
Sub Cell Biology +3 more
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Rewiring of the phosphoproteome executes two meiotic divisions in budding yeast
The cell cycle is ordered by a controlled network of kinases and phosphatases. To generate gametes via meiosis, two distinct and sequential chromosome segregation events occur without an intervening S phase. How canonical cell cycle controls are modified
Lori B Koch +4 more
doaj +1 more source
The c-SMAC: Sorting It All Out (or in) [PDF]
?? Lin, Joseph, Mark Miller, and Andrey Shaw. 2005. Originally published in The Journal of Cell Biology. doi: 10.1083/jcb.200503032.T cells integrate and transduce the key signals necessary\ud to mount an appropriate immune response.
Andrey S. Shaw +5 more
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AbstractNearly 10% of all plant proteins belong to the zinc (Zn) proteome. They require Zn either for catalysis or as a structural element. Most of the protein-bound Zn in eukaryotic cells is found in the cytosol. The fundamental differences between transition metal cations in the stability of their complexes with organic ligands, as described by the ...
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Connecting the neuronal proteome: Unraveling protein dynamics in neurons using Mass Spectrometry-based proteomics [PDF]
Similarly to the amazon rainforest which is formed by a multitude of different trees, many of them growing around and on top of each other with their branches and roots tightly interconnected, the human brain is composed by approximately 100 billion ...
Stucchi, Riccardo +2 more
core
The Tyrosine Phosphatase CD148 is Excluded from the Immunologic Synapse and Down-regulates Prolonged T Cell Signaling [PDF]
?? Joseph Lin and Arthur Weis, 2011. Originally published in The Journal of Cell Biology. doi: 10.1083/jcb.200303040.CD148 is a receptor-like protein tyrosine phosphatase\ud up-regulated on T cells after T cell receptor\ud (TCR) stimulation.
Arthur Weiss +3 more
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The cell biology of glycosphingolipids
Glycosphingolipids, a family of heterogeneous lipids with biophysical properties conserved from fungi to mammals, are key components of cellular membranes. Because of their tightly packed backbone, they have the ability to associate with other sphingolipids and cholesterol to form microdomains called lipid rafts, with which a variety of proteins ...
Degroote, S. +2 more
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