Results 1 to 10 of about 599,411 (264)

Single-nucleus and spatial transcriptomics reveal intestinal cellular heterogeneity, differentiation, and cell communication mechanisms in SAP-induced intestinal injury [PDF]

Frontiers in Immunology
BackgroundAcute pancreatitis (AP) ranges from mild to severe, and severe disease frequently causes multi-organ damage, with intestinal injury being a major complication. The mechanisms underlying SAP-induced intestinal injury remain unclear, particularly
Lechang Zhang, Changqin Xu, Tong Su, Tong Xiao, Xu Yi, Yuemin Feng, Jing Wang, Shulei Zhao   +7 more
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Controlling Synthetic Cell-Cell Communication [PDF]

Frontiers in Molecular Biosciences, 2022
Synthetic cells, which mimic cellular function within a minimal compartment, are finding wide application, for instance in studying cellular communication and as delivery devices to living cells. However, to fully realise the potential of synthetic cells, control of their function is vital.
Smith, J, Chowdhry, R, Booth, M
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In-depth mining of single-cell transcriptome reveals the key immune-regulated loops in age-related macular degeneration

Frontiers in Molecular Neuroscience, 2023
IntroductionAge-related macular degeneration (AMD), an ever-increasing ocular disease, has become one of the leading causes of irreversible blindness. Recent advances in single-cell genomics are improving our understanding of the molecular mechanisms of ...
Wencan Wang, Wencan Wang, Wencan Wang, Peng Lin, Peng Lin, Peng Lin, Siyu Wang, Siyu Wang, Siyu Wang, Guosi Zhang, Guosi Zhang, Guosi Zhang, Chong Chen, Chong Chen, Chong Chen, Xiaoyan Lu, Xiaoyan Lu, Xiaoyan Lu, Youyuan Zhuang, Youyuan Zhuang, Youyuan Zhuang, Jianzhong Su, Jianzhong Su, Jianzhong Su, Jianzhong Su, Hong Wang, Hong Wang, Hong Wang, Hong Wang, Liangde Xu, Liangde Xu, Liangde Xu, Liangde Xu   +32 more
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Single-cell mechanistic studies of radiation-mediated bystander effects

Frontiers in Immunology, 2022
Ionizing radiation (IR) has been widely used in the diagnosis and treatment of clinical diseases, with radiation therapy (RT) being particularly rapid, but it can induce “bystander effects” that lead to biological responses in non-target cells after ...
Xueqiong Han, Yixuan Chen, Nan Zhang, Chengyu Huang, Guangyao He, Ting Li, Mengxin Wei, Qiong Song, Shaowen Mo, Yufeng Lv   +9 more
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Docosahexaenoic fatty acid reduces the pro‐inflammatory response induced by IL-1β in astrocytes through inhibition of NF-κB and AP-1 transcription factor activation

BMC Neuroscience, 2021
Background Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurological pathologies may exacerbate ...
Emilia Zgórzyńska, Dawid Stulczewski, Barbara Dziedzic, Kuan-Pin Su, Anna Walczewska   +4 more
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Preconditioning Methods to Improve Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Bone Regeneration—A Systematic Review

Biology, 2022
Mesenchymal stromal cells (MSCs) have long been used in research for bone regeneration, with evidence of their beneficial properties. In the segmental area of MSC-based therapies, MSC-derived extracellular vesicles (EVs) have also shown great therapeutic
Fernanda Campos Hertel, Aline Silvestrini da Silva, Adriano de Paula Sabino, Fabrício Luciani Valente, Emily Correna Carlo Reis   +4 more
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Exosomes Regulate Interclonal Communication on Osteogenic Differentiation Among Heterogeneous Osteogenic Single-Cell Clones Through PINK1/Parkin-Mediated Mitophagy

Frontiers in Cell and Developmental Biology, 2021
Mesenchymal stem cells (MSCs) are intrinsically heterogeneous and are comprised of distinct subpopulations that differ in their differentiation potential.
Dongdong Fei, Dongdong Fei, Yanmin Xia, Qiming Zhai, Qiming Zhai, Yazheng Wang, Feng Zhou, Wanmin Zhao, Xiaoning He, Qintao Wang, Yan Jin, Bei Li   +11 more
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Integrating cell interaction with transcription factors to obtain a robust gene panel for prognostic prediction and therapies in cholangiocarcinoma

Frontiers in Genetics, 2022
Objective: The efficacy of immunotherapy for cholangiocarcinoma (CCA) is blocked by a high degree of tumor heterogeneity. Cell communication contributes to heterogeneity in the tumor microenvironment.
Tingjie Wang, Chuanrui Xu, Dan Xu, Xiaofei Yang, Xiaofei Yang, Xiaofei Yang, Yaxin Liu, Xiujuan Li, Zihang Li, Ningxin Dang, Yi Lv, Zhijing Zhang, Lei Li, Kai Ye, Kai Ye, Kai Ye, Kai Ye, Kai Ye, Kai Ye   +18 more
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Quorum Sensing-Mediated Lipid Oxidation Further Regulating the Environmental Adaptability of Aspergillus ochraceus

Metabolites, 2023
Quorum sensing (QS) is a cellular strategy of communication between intra- and inter-specific microorganisms, characterized by the release of quorum sensing molecules (QSMs) that achieve coordination to adaptation to the environment.
Jing Gao, Huiqing Liu, Zhenzhen Zhang, Zhihong Liang   +3 more
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Cell-cell communication in carcinogenesis [PDF]

Frontiers in Bioscience, 1998
To explain the complex carcinogenic process by which a single normal cell in human beings can be converted to an invasive and metastatic cancer cell, a number of experimental findings, epidemiological observations and their associated hypothesis/theories have been integrated in this review.
J E, Trosko, R J, Ruch
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