Results 1 to 10 of about 13,173,007 (100)

Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling

eLife, 2023
Oral inflammatory diseases such as apical periodontitis are common bacterial infectious diseases that may affect the periapical alveolar bone tissues.
Yi Fan, Ping Lyu, Ruiye Bi, Chen Cui, Ruoshi Xu, Clifford J Rosen, Quan Yuan, Chenchen Zhou   +7 more
doaj   +1 more source

A Global Regulatory Network for Dysregulated Gene Expression and Abnormal Metabolic Signaling in Immune Cells in the Microenvironment of Graves’ Disease and Hashimoto’s Thyroiditis

Frontiers in Immunology, 2022
BackgroundAlthough the pathogenetic mechanisms of Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) have been elucidated, the molecular mechanisms by which the abnormal immune function of cellular subpopulations trigger an autoimmune attack on ...
Haitao Zheng, Jie Xu, Yongli Chu, Wenzhou Jiang, Wenjie Yao, Shaowen Mo, Xicheng Song, Jin Zhou   +7 more
doaj   +1 more source

Docosahexaenoic fatty acid reduces the pro‐inflammatory response induced by IL-1β in astrocytes through inhibition of NF-κB and AP-1 transcription factor activation

BMC Neuroscience, 2021
Background Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurological pathologies may exacerbate ...
Emilia Zgórzyńska, Dawid Stulczewski, Barbara Dziedzic, Kuan-Pin Su, Anna Walczewska   +4 more
doaj   +1 more source

Circulating circRNA: a social butterfly in tumors

Frontiers in Oncology, 2023
Circular RNAs (circRNAs) are a class of single-stranded non-coding RNAs that form circular structures through irregular splicing or post-splicing events.
Shuo Miao, Shuo Miao, Qingsong Zhang
doaj   +1 more source

Hepatocytes infected with hepatitis C virus change immunological features in the liver microenvironment [PDF]

Clinical and Molecular Hepatology, 2023
Hepatitis C virus (HCV) infection is remarkably efficient in establishing viral persistence, leading to the development of liver cirrhosis and hepatocellular carcinoma (HCC).
Soo-Jeung Park, Young S. Hahn
doaj   +1 more source

Treatment with tumor-treating fields (TTFields) suppresses intercellular tunneling nanotube formation in vitro and upregulates immuno-oncologic biomarkers in vivo in malignant mesothelioma

eLife, 2023
Disruption of intercellular communication within tumors is emerging as a novel potential strategy for cancer-directed therapy. Tumor-Treating Fields (TTFields) therapy is a treatment modality that has itself emerged over the past decade in active ...
Akshat Sarkari, Sophie Korenfeld, Karina Deniz, Katherine Ladner, Phillip Wong, Sanyukta Padmanabhan, Rachel I Vogel, Laura A Sherer, Naomi Courtemanche, Clifford Steer, Kerem Wainer-Katsir, Emil Lou   +11 more
doaj   +1 more source

Nanomaterial Exposure, Extracellular Vesicle Biogenesis and Adverse Cellular Outcomes: A Scoping Review

Nanomaterials, 2022
The progressively increasing use of nanomaterials (NMs) has awakened issues related to nanosafety and its potential toxic effects on human health. Emerging studies suggest that NMs alter cell communication by reshaping and altering the secretion of ...
Thais S. M. Lima, Wanderson Souza, Luths R. O. Geaquinto, Priscila L. Sanches, Ewa. L. Stepień, João Meneses, Eli Fernández-de Gortari, Nicole Meisner-Kober, Martin Himly, José M. Granjeiro, Ana R. Ribeiro   +10 more
doaj   +1 more source

Intercellular Communication Reveals Therapeutic Potential of Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer

Biomolecules, 2022
(1) Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with high intra-tumoral heterogeneity. The epithelial-mesenchymal transition (EMT) is one of the inducers of cancer metastasis and migration.
Yang Liu, Yu Fang, Lili Bao, Feng Wu, Shilong Wang, Siyu Hao   +5 more
doaj   +1 more source

Caveolae as Potential Hijackable Gates in Cell Communication

Frontiers in Cell and Developmental Biology, 2020
Caveolae are membrane microdomains described in many cell types involved in endocytocis, transcytosis, cell signaling, mechanotransduction, and aging. They are found at the interface with the extracellular environment and are structured by caveolin and ...
Maria Dudãu, Maria Dudãu, Elena Codrici, Cristiana Tanase, Cristiana Tanase, Mihaela Gherghiceanu, Mihaela Gherghiceanu, Ana-Maria Enciu, Ana-Maria Enciu, Mihail E. Hinescu, Mihail E. Hinescu   +10 more
doaj   +1 more source

Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells

Frontiers in Immunology, 2021
The role of Pannexin (PANX) channels during collective and single cell migration is increasingly recognized. Amongst many functions that are relevant to cell migration, here we focus on the role of PANX-mediated adenine nucleotide release and associated ...
Paloma A. Harcha, Tamara López-López, Adrián G. Palacios, Pablo J. Sáez   +3 more
doaj   +1 more source