Results 71 to 80 of about 595,345 (267)

Characterizing the Tumor Microenvironment and Its Prognostic Impact in Breast Cancer

Cells
The tumor microenvironment (TME) is crucial in cancer development and therapeutic response. Immunotherapy is increasingly recognized as a critical component of cancer treatment.
Wenjuan Zhang, Alex Lee, Amit K. Tiwari, Mary Qu Yang   +3 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication

Journal of Extracellular Vesicles, 2017
In the past years, extracellular vesicles (EVs) have become an important field of research since EVs have been found to play a central role in biological processes.
Rodrigo P. Soares, Patrícia Xander, Adriana Oliveira Costa, Antonio Marcilla, Armando Menezes-Neto, Hernando Del Portillo, Kenneth Witwer, Marca Wauben, Esther Nolte-`T Hoen, Martin Olivier, Miriã Ferreira Criado, Luis Lamberti P. da Silva, Munira Muhammad Abdel Baqui, Sergio Schenkman, Walter Colli, Maria Julia Manso Alves, Karen Spadari Ferreira, Rosana Puccia, Peter Nejsum, Kristian Riesbeck, Allan Stensballe, Eline Palm Hansen, Lorena Martin Jaular, Reidun Øvstebø, Laura de la Canal, Paolo Bergese, Vera Pereira-Chioccola, Michael W. Pfaffl, Joëlle Fritz, Yong Song Gho, Ana Claudia Torrecilhas   +30 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Expanding Role of Vesicles Containing Aquaporins

Cells, 2018
In animals and plants, membrane vesicles containing proteins have been defined as key for biological systems involving different processes such as trafficking or intercellular communication.
M Carmen Martinez-Ballesta, Paula Garcia-Ibañez, Lucía Yepes-Molina, Juan José Rios, Micaela Carvajal   +4 more
doaj   +1 more source

Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling [PDF]

, 2022
Slaven Crnković, Francesco Valzano, Elisabeth Fließer, Juergen Gindlhuber, Helene Thekkekara Puthenparampil, Maria C. Basil, Michael P. Morley, Jeremy Katzen, Elisabeth Gschwandtner, Walter Klepetko, Edward Cantu, Heimo Wolinski, Horst Olschewski, Jörg Lindenmann, You‐Yang Zhao, Edward E. Morrisey, Leigh M. Marsh, Grażyna Kwapiszewska   +17 more
openalex   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

lncRNA Profiling of Exosomes and Its Communication Role in Regulating Silica-Stimulated Macrophage Apoptosis and Fibroblast Activation

Biomolecules
Long-term silica particle exposure leads to interstitial pulmonary inflammation and fibrosis, called silicosis. Silica-activated macrophages secrete a wide range of cytokines resulting in persistent inflammation. In addition, silica-stimulated activation
Jiaqi Ban, Shuai Chang, Pengwei Ma, Xin Wang, Fangwei Liu   +4 more
doaj   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source