Results 61 to 70 of about 691,235 (310)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Optimisation of Lambertian order for indoor non-directed optical wireless communication [PDF]

, 2012
This paper studies the optimised Lambertian order (OLO) of light-emitting diodes (LEDs) for an indoor non-directed line of sight optical wireless communication (NLOS-OWC) systems.
Ghassemlooy, Zabih, H. Le Minh, Z. Ghassemlooy, Minh, Hao Le, Wu, Dehao, D. Wu, Tang, Xuan, Khalighi, Mohammad-Ali, Rajbhandari, Sujan, M. A. Khalighi, S. Rajbhandari, Le Minh, Hoa   +11 more
core   +1 more source

Simultaneous induction of vasculature and neuronal network formation on a chip reveals a dynamic interrelationship between cell types

, 2023
Background: Neuronal networks receive and deliver information to regulate bodily functions while the vascular network provides oxygen, nutrients, and signaling molecules to tissues.
Minna Kelloniemi, Susanna Narkilahti, Alma Yrjänäinen, Lotta Isosaari, Hanna Vuorenpää, Pakarinen, Toni Karri, Fikret Emre Kapucu, Susanna Miettinen, Yrjänäinen, Alma, Kapucu, Fikret Emre, Isosaari, Lotta, Narkilahti, Susanna, Vuorenpää, Hanna, Kelloniemi, Minna, Toni-Karri Pakarinen, Miettinen, Susanna   +15 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Cell communication and immunology: part 1 [Frontiers of biomedical engineering ]

, 2016
Educação Superior::Ciências Biológicas::BioquímicaEducação Superior::Ciências Biológicas::Biologia GeralEducação Superior::Engenharias::Engenharia BiomédicaPresents a lecture by professor Saltzman.
Saltzman, W. Mark
core   +1 more source

ROS mediates interferon gamma induced phosphorylation of Src, through the Raf/ERK pathway, in MCF-7 human breast cancer cell line [PDF]

, 2017
Interferon gamma (IFN-ɣ) is a pleiotropic cytokine which plays dual contrasting roles in cancer. Although IFN-ɣ has been clinically used to treat various malignancies, it was recently shown to have protumorigenic activities. Reactive oxygen species (ROS)
Asad Zeidan, Nabil El-Zein, Badran, Bassam M., Bassam Badran, Kazem Zibara, Nouhad Kassem, El-Zein, Nabil, Kassem, Nouhad A., Zeidan, Asad, Hassan Bjeije, Bjeije, Hassan, Zibara, Kazem   +11 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Cell communication and immunology: part 1 [Frontiers of biomedical engineering ]

, 2011
Educação Superior::Ciências Biológicas::BioquímicaEducação Superior::Ciências Biológicas::Biologia GeralEducação Superior::Engenharias::Engenharia BiomédicaPresents a lecture by professor Saltzman.
Saltzman, W. Mark
core   +1 more source