Results 101 to 110 of about 10,810 (302)

Cardiac Hypertrophy Changes Compartmentation of cAMP in Non-Raft Membrane Microdomains

, 2021
3′,5′-Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger which plays critical roles in cardiac function and disease. In adult mouse ventricular myocytes (AMVMs), several distinct functionally relevant microdomains with tightly ...
Viacheslav O. Nikolaev, Nikoleta Pavlaki, Birgit Geertz, Alexander Froese, Kirstie A. De Jong   +4 more
core   +1 more source

New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy

EMBO Molecular Medicine, 2020
KLF4 plays a critical role in determining cell fate responding to various stresses or oncogenic signaling. Here, we demonstrated that KLF4 is tightly regulated by poly(ADP‐ribosyl)ation (PARylation).
Zhuan Zhou, Furong Huang, Indira Shrivastava, Rui Zhu, Aiping Luo, Michael Hottiger, Ivet Bahar, Zhihua Liu, Massimo Cristofanilli, Yong Wan   +9 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Compartmentation of the Nucleolar Processing Proteins in the Granular Component is a CK2-driven Process.

, 2006
To analyze the compartmentation of nucleolar protein complexes, the mechanisms controlling targeting of nucleolar processing proteins onto rRNA transcription sites has been investigated.
Hernandez-Verdun, Danièle, Junéra, Henriette,, Louvet, Emilie, Berthuy, Isabelle   +3 more
core   +1 more source

Chemodiversity of the Glucosinolate-Myrosinase System at the Single Cell Type Resolution

Frontiers in Plant Science, 2019
Glucosinolates (GLSs) are a well-defined group of specialized metabolites, and like any other plant specialized metabolites, their presence does not directly affect the plant survival in terms of growth and development.
Shweta Chhajed, Shweta Chhajed, Biswapriya B. Misra, Biswapriya B. Misra, Nathalia Tello, Nathalia Tello, Sixue Chen, Sixue Chen, Sixue Chen, Sixue Chen   +9 more
doaj   +1 more source

Transmembrane Protein Oxygen Content and Compartmentalization of Cells

PLoS ONE, 2008
Recently, there was a report that explored the oxygen content of transmembrane proteins over macroevolutionary time scales where the authors observed a correlation between the geological time of appearance of compartmentalized cells with atmospheric oxygen concentration.
Rajkumar Sasidharan, Andrew Smith, Mark Gerstein   +2 more
openaire   +4 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Cerebellar compartmentation of prion pathogenesis

, 2017
International audienceIn prion diseases, the brain lesion profile is influenced by the prion “strain” properties, the invasion route to the brain, and still unknown host cell‐specific parameters. To gain insight into those endogenous factors, we analyzed
Vincent Béringue, Demais, Valérie, Béringue, Vincent, Catherine Vidal, Guillemain, Aurélie, Grant, Nancy, Benoit Schneider, Haeberlé, Anne-Marie, Vidal, Catherine, Boudet-Devaud, François, Demuth, Stanislas, Valérie Demais, Anne-Marie Haeberlé, Yannick Bailly, Schneider, Benoit, Stanislas Demuth, Kellermann, Odile, Bailly, Yannick, Odile Kellermann, Ragagnin, Audrey, Juliette Ezpeleta, Aurélie Guillemain, François Boudet-Devaud, Audrey Ragagnin, Ezpeleta, Juliette, Nancy J. Grant   +25 more
core   +1 more source