Results 1 to 10 of about 593 (218)
Mechanical Fractionation of Cultured Neuronal Cells into Cell Body and Neurite Fractions
Bio-Protocol, 2021 Many cells contain spatially defined subcellular regions that perform specialized tasks enabled by localized proteins. The subcellular distribution of these localized proteins is often facilitated by the subcellular localization of the RNA molecules that
Ankita Arora +3 more
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Application of RNA subcellular fraction estimation method to explore RNA localization regulation
G3: Genes, Genomes, Genetics, 2021 RNA localization is involved in multiple biological processes. Recent advances in subcellular fractionation-based sequencing approaches uncovered localization pattern on a global scale. Most of existing methods adopt relative localization ratios (such as
Xiaomin Dai +8 more
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Scientific Reports, 2022 Subcellular organelles have long been an interest in biochemical research and drug development as the isolation of those organelles can help to probe protein functions and elucidate drug disposition within the cell.
Xiazi Qiu +2 more
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Biomedicines, 2021 Alzheimer’s disease (AD) is characterized by the accumulation of extracellular plaques composed by amyloid-β (Aβ) and intracellular neurofibrillary tangles of hyperphosphorylated tau.
Tânia Fernandes +8 more
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Subcellular partitioning of protein kinase activity revealed by functional kinome profiling
Scientific Reports, 2022 Protein kinases and their substrates form signaling networks partitioned across subcellular compartments to facilitate critical biological processes. While the subcellular roles of many individual kinases have been elucidated, a comprehensive assessment ...
Lauren Wegman-Points +6 more
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HMG CoA reductase of intestinal mucosa and liver of the rat
Journal of Lipid Research, 1972 Methods were developed for the determination of HMG CoA (3-hydroxy-3-methylglutaryl CoA) reductase activity in subcellular fractions of intestinal mucosa and liver of Wistar strain rats.
S. Shefer +3 more
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BMC Plant Biology, 2010 Background Because of the increasing quantity and high toxicity to humans of polycyclic aromatic hydrocarbons (PAHs) in the environment, several bioremediation mechanisms and protocols have been investigated to restore PAH-contaminated sites.
Zhang Yi +3 more
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The subcellular distribution of platelet lipids labeled by acetate-l-14C
Journal of Lipid Research, 1971 The lipids of intact human platelets were labeled in vitro with acetate-1-14C, and the distribution of radioactivity in individual fatty acids and in lipid classes was examined in platelet subcellular fractions separated by sucrose density gradient ...
DANIEL DEYKIN
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Neurobiology of Disease, 2003 This study was performed to determine the effect of prolonged status epilepticus on the activity and subcellular location of a neuronally enriched, calcium-regulated enzyme, calcineurin. Brain fractions isolated from control animals and rats subjected to
Jonathan E Kurz +3 more
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Cells, 2019 Obesity is frequently associated with excessive accumulation of lipids in ectopic tissue and presents a major risk factor for type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). Diacylglycerols (DAGs) and ceramides (CERs) were identified
Christina Preuss +7 more
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