Results 81 to 90 of about 10,810 (302)

Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution

Biology Direct, 2010
Background The transition from prokaryotes to eukaryotes was the most radical change in cell organisation since life began, with the largest ever burst of gene duplication and novelty.
Cavalier-Smith Thomas
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells [PDF]

, 2010
hESCs (human embryonic stem cells) offer great potential for pharmaceutical research and development and, potentially, for therapeutic use. However, improvements in cell culture are urgently required to allow the scalable production of large numbers of ...
Baillie, George S., Nicole M. Kane, Fergus R. McKenzie, Kane, N.M., Achamma Abraham, George S. Baillie, Allcock, R.W., John McAbney, Peter Burton, Baillie, G.S., Graeme Milligan, Kane, Nicole M., Houslay, Miles D., Andrew H. Baker, Robert W. Allcock, Gilmour, J., Gilmour, Jane, Mountford, Joanne C., Joanne C. Mountford, Jiang, Zhong, Miles D. Houslay, Adams, D.R., Adams, David R., McAbney, J., McCahill, Angela, Milligan, Graeme, McKenzie, F.R., Burton, Peter, Abraham, Achamma, Baker, Andrew H., McCahill, A., Jane Gilmour, Jiang, Z., Baker, A.H., Mountford, J.C., Angela McCahill, Abraham, A., Houslay, M.D., McAbney, John, McKenzie, Fergus R., Burton, P., David R. Adams, Milligan, G., Allcock, Robert W., Zhong Jiang   +44 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls

, 2007
Arabidopsis cell walls contain large amounts of pectins and hemicelluloses, which are predominantly synthesized via the common precursor UDP-glucuronic acid.
Tenhaken, Raimund, Klinghammer, Michaela
core   +1 more source

High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei. [PDF]

, 2014
In the bloodstream of mammalian hosts, the sleeping sickness parasite, Trypanosoma brucei, exists as a proliferative slender form or a nonproliferative, transmissible, stumpy form.
Auer, Manfred, Ivens, A, Matthews, KR, Matthews, Keith R., Collie, I, Ivens, Alasdair, Auer, M, Gray, David, McGregor, Paula, Macgregor, Paula, Matthews, Keith R; id_orcid, Gray, David; id_orcid, Collie, Iain, Shave, S, MacGregor, P, Gray, D, Shave, Steven   +16 more
core   +1 more source

Sobre la ecofisiología de plantas halofitas y desérticas

Acta Biológica Colombiana, 1990
Some aspects of the tolerance of higher plants to salt environments and dry zones are pointed out. Salt and drought tolerance arc mostly based on selective ion absorption, osmoregulation, cell compartmentation and synthesis of osmotic compounds.
Albert R. F. Hotterer, G. Hertenberger, J. Polanía   +2 more
doaj  

Segregation of fluorescent membrane lipids into distinct micrometric domains: evidence for phase compartmentation of natural lipids?

PLoS ONE, 2011
BackgroundWe recently reported that sphingomyelin (SM) analogs substituted on the alkyl chain by various fluorophores (e.g. BODIPY) readily inserted at trace levels into the plasma membrane of living erythrocytes or CHO cells and spontaneously ...
Ludovic D'auria, Patrick Van der Smissen, Frédéric Bruyneel, Pierre J Courtoy, Donatienne Tyteca   +4 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source